Effect of lysophosphatidylcholine on behavior and structure of phosphatidylcholine liposomes

Science in China. Series C, Life Sciences
J Z LuF Huang

Abstract

Differential scanning calorimetry (DSC), fluorescence polarization and X-ray diffraction were performed to investigate the kinetics of the micellar to the lamellar phase transition of dipalmitoylphosphatidylcholine/1-palmitoylphosphatidylcholine (16:0 LPC/DPPC) liposomes at gel phase. With a 16:0 LPC concentration up to 27 mol% only the sharp main transition with relatively high enthalpy (DeltaH) values of DPPC was observed. Increasing 16 : 0 LPC concentration, the phase transition was broadened and the transition enthalpy was decreased and finally totally disappeared. The fluorescence probes of 3AS, 9AS, 12AS, and 16AP were employed, respectively, to detect the mobility of various sites of carbon chains of DPPC or 16:0 LPC/DPPC liposomes. It was shown that DPPC liposomes formed in the absence of 16:0 LPC always had a fluidity gradient in both gel and liquid-crystalline phase, while in the presence of 14.1 mol% and 27.0 mol% 16:0 LPC in the mixtures, the fluidity gradient tended to disappear below 40 degrees C. In the case of 27.0 mol% 16:0 LPC in the 16:0 LPC/DPPC mixtures the polarization of the sixteenth carbon of acyl chains was similar to that of the sixth at 10 degrees C. Small-angle X-ray diffraction showed that when inc...Continue Reading

References

Jul 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·Y AsaokaY Nishizuka
Jan 1, 1980·Biochimica Et Biophysica Acta·C J Van EchteldJ de Gier
Feb 22, 1994·Biochemistry·P L YeagleT D Flanagan
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