PMID: 6163948Jan 1, 1980Paper

Effect of lysozyme on mycobacteria

Microbiology and Immunology
F Kanetsuna

Abstract

The effect of lysozyme on the growth of several strains of mycobacteria was examined at pH 5.0-7.0 in Dubos medium containing various concentrations of lysozyme (100-2,000 microgram/ml). Mycobacterium smegmatis and M. phlei were susceptible to lysozyme at pH 5.0-7.0. The effect of lysozyme was marked between pH 6.0 and 7.0 and the colony counts were reduced to approximately 0.1-10% after incubation with 100 micrograms of lysozyme per ml for 48 hr. At pH 5.0, 10-40% of the organisms survived treatment with 1,000 micrograms of lysozyme per ml for 48 hr. M. bovis strain BCG, M. tuberculosis, and M. fortuitum appeared to be more resistant to lysozyme than M. smegmatis and M. phlei. M. smegmatis and M. phlei did not contain detectable amounts of poly-L-glutamic acid, although the susceptibility of the mycobacteria to lysozyme did not correlate with the amounts of the polymer in the cell walls. The role of lysozyme in animal infections with so-called saprophytic mycobacteria is discussed.

References

Aug 1, 1978·The Journal of Experimental Medicine·J Schnyder, M Baggiolini
Aug 1, 1978·Journal of General Microbiology·P S JackettD B Lowrie
Jan 1, 1978·Infection and Immunity·G R Hemsworth, I Kochan
Aug 1, 1977·Japanese Journal of Medical Science & Biology·E Kondo, K Kanai
Jul 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·M B GorenJ A Armstrong
Aug 1, 1976·Japanese Journal of Medical Science & Biology·E Kondo, K Kanai
Jan 1, 1974·Infection and Immunity·C A GoldenD R Spriggs
Dec 1, 1968·Japanese Journal of Medical Science & Biology·K Kanai, E Kondo
May 1, 1956·The Journal of Experimental Medicine·J G HIRSCH
Jan 1, 1957·The Journal of Experimental Medicine·C C SHEPARD
Feb 1, 1957·Biochimica Et Biophysica Acta·H BLOCHH NOLL

❮ Previous
Next ❯

Citations

Mar 1, 1982·Archives of Microbiology·J WeckeP Giesbrecht
Sep 11, 2018·ELife·Alam García-HerediaM Sloan Siegrist
Nov 22, 2015·The Journal of Biological Chemistry·Deepti SethiKanak L Dikshit
Oct 29, 2000·Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·J S Ferguson, L S Schlesinger
Jul 20, 2021·Antimicrobial Agents and Chemotherapy·Loes van SchieNico Callewaert

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.