PMID: 9164088Apr 1, 1997Paper

Effect of macrolide antibiotics on neutrophil function in human peripheral blood

Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases
E Sugihara

Abstract

Since "small-dose and long-term" administration of erythromycin (EM) was shown to be efficacious in the treatment of chronic respiratory disease, the modulation of host defense responses by EM has attracted much attention. Although there is considerable controversy, it was recently demonstrated that EM activity reduces neutrophil function. In this study, we investigated the in vitro effects of the macrolides erythromycin (EM), a 14-membered ring, azithromycin (AZM), a 15-membered ring and rokitamycin (RKM), a 16-membered ring macrolide, on neutrophil function. The DCFH-DA method and cytochrome C method were used for assay of active oxygen generation and the Boyden-chamber method was used for assay of chemotaxis. EM and AZM, both of which have been shown to be clinically effective in the treatment of Diffuse panbronchiolitis (DPB), significantly suppressed active oxygen generation and chemotaxis of neutrophils at low concentrations equivalent to therapeutic doses (0.5 approximately 1.0 microgram/ml, p < 0.05), whereas the clinically ineffective RKM did not. The in vitro inhibitory effects of EM and AZM on active oxygen generation and chemotaxis of neutrophils demonstrated in the present study may be responsible for the therapeut...Continue Reading

Citations

Nov 8, 2001·European Journal of Pharmacology·O CulićM J Parnham
Jan 15, 2004·American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions·Joanne M WolterJoseph G McCormack
Sep 16, 2000·The Journal of Dermatology·M Komine, K Tamaki
Sep 6, 2014·Medical Microbiology and Immunology·Olachi AnuforomLaura V Piddock
Dec 29, 1998·The Journal of Eukaryotic Microbiology·F L Schuster, G S Visvesvara
Oct 27, 2015·Trends in Immunology·Eva S Gollwitzer, Benjamin J Marsland
Aug 23, 2008·Proceedings of the National Academy of Sciences of the United States of America·Iwao KomuroSatoshi Omura
Apr 9, 2005·The Journal of Antibiotics·Kiminari YoshidaSatoshi Omura
Nov 3, 2020·Frontiers in Immunology·Trim LajqiHannes Hudalla
Sep 27, 2020·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Chien-Wei LeeDaniel Tsung-Ning Huang

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