Effect of macrophage colony-stimulating factor (M-CSF) on mouse immune responses in vivo

Immunopharmacology and Immunotoxicology
T SakuraiK Motoyoshi

Abstract

We examined the effects of recombinant human M-CSF (rhM-CSF) on mouse macrophages and immune responses in vivo. Intraperitoneal administration of rhM-CSF (20-500 microgram/ml) increased Mac-1+ cell numbers in the peritoneal cavity. The tumoricidal activities of the macrophages from vehicle-administered (V-M phi) and from rhM-CSF-administered (M-M phi) mice were the same as those observed in vitro. However, when activated by lipopolysaccharide (LPS), the tumoricidal activity of M-M phi was stronger than that of V-M phi. Intravenous administration of rhM-CSF (500 micrograms/gk) increased the number of spleen cells. Flow cytometric analysis showed that administration of rhM-CSF increased Mac-1+, B220+ and NK 1.1+ cell counts in the spleen. However, CD4+ and CD8+ cell numbers did not change. Concomitant increases were observed in levels of IL-4 and IL-10 in mouse serum following rhM-CSF administration, but no significant changes were observed in the serum level of IFN-gamma. In experiments involving mouse immune responses, the administration of rhM-CSF reduced the contact sensitivity (CS) reaction against picryl chloride (PC) and augmented IgE production in response to 2,4-dinitrophenyl (DNP), but did not affect the production of e...Continue Reading

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Citations

Mar 29, 2008·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Staley A Brod, Zachary Hood
Jan 5, 2002·Journal of Virology·Aouatef DjerabaPascale Quéré
Sep 22, 2015·The Journal of Clinical Investigation·Séverine BézieCarole Guillonneau
Nov 18, 2010·Journal of Neuroimmunology·Staley A Brod, Zachary M Hood
Oct 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·David A Hume

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