Effect of magnesium--aluminum hydroxide and kaolin--pectin on absorption of digoxin from tablets and capsules

Journal of Clinical Pharmacology
M D AllenT W Smith

Abstract

Twelve healthy fasting volunteers received two 0.2-mg digoxin capsules or tablets with 60 ml water, 60 ml Maalox, or 60 ml Kaopectate in a randomized, single-dose, six-way crossover study. Concentrations of digoxin in multiple plasma samples and in all urine collected during the 24 hours after each dose were determined by radioimmunoassay. Compared to the water treatment, administration of both tablets and capsules with Maalox or Kaopectate reduced the peak digoxin plasma concentrations but did not significantly influence the time of peak concentration. Neither Maalox nor Kaopectate influenced the area under the 24-hour plasma concentration--time curve for either tablets or capsules. However, 24-hour urinary recovery of digoxin from tablets tended to be reduced by Maalox and Kaopectate; this was not the case with capsules. Digoxin capsules may have an advantage over currently available tablets in clinical situations requiring digoxin coadministration with nonabsorbable gastrointestinal preparations.

References

Sep 1, 1978·Clinical Pharmacology and Therapeutics·R I ShaderM D Allen
Mar 1, 1977·Clinical Pharmacology and Therapeutics·J Lindenbaum
Nov 1, 1978·Clinical Pharmacology and Therapeutics·D J GreenblattR I Shader
Nov 1, 1978·Journal of Pharmaceutical Sciences·K S AlbertJ G Wagner
Feb 1, 1976·Clinical Pharmacology and Therapeutics·D J GreenblattJ Koch-Weser
Jan 1, 1976·Clinical Pharmacokinetics·D J GreenblattJ Koch-Weser
Jan 1, 1976·Pharmacology·D J GreenblattT W Smith
Nov 4, 1976·The New England Journal of Medicine·D D Brown, R P Juhl
Dec 1, 1975·Clinical Pharmacology and Therapeutics·G I MallisJ Lindenbaum
Jun 1, 1976·Clinical Pharmacology and Therapeutics·B F JohnsonG A Sabey
Sep 27, 1973·The New England Journal of Medicine·D J GreenblattT W Smith
Nov 27, 1969·The New England Journal of Medicine·T W SmithE Haber

❮ Previous
Next ❯

Citations

May 1, 1985·Journal of the American College of Cardiology·F I Marcus
Mar 3, 1983·The New England Journal of Medicine·W M Haun
Sep 29, 2011·Drugs·Ryuichi Ogawa, Hirotoshi Echizen
Aug 1, 1982·American Heart Journal·H I Bussey
Jul 1, 1987·Journal of Clinical Pharmacology·B F JohnsonV Shekar
Jul 1, 1987·Drug Intelligence & Clinical Pharmacy·P F D'Arcy, J C McElnay

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Quarterly Reviews on Drug Metabolism and Drug Interactions
B F Johnson, D R Urbach
The New England Journal of Medicine
J E Doherty
© 2021 Meta ULC. All rights reserved