Effect of magnesium sulfate on contractile force and intracellular calcium concentration in pregnant human myometrium

American Journal of Obstetrics and Gynecology
Victor P FominWilliam W Hurd

Abstract

This study was undertaken to evaluate the effects of magnesium sulfate (MgSO4) on contractile force and increases in free intracellular calcium concentration ([Ca2+]i) in human myometrial strips from pregnant women. Simultaneous measurements of isometric tension and [Ca2+]i were measured in myometrial strips obtained at the time of cesarean delivery from pregnant nonlaboring women at term with the use of a fluorescence spectrometer equipped with a displacement force transducer. Changes in [Ca2+]i were measured with fura-2, a Ca(2+)-sensitive fluorescent probe. Myometrial strips were exposed to MgSO4 (5 or 10 mmol/L) for 5, 10, 20, and 30 minutes and observed for spontaneous contractions or stimulated with either oxytocin (OT; 0.1 micromol/L) or potassium chloride (KCl; 90 mmol/L). MgSO4 reduced spontaneous, OT, and KCl-evoked contractions and increases in [Ca2+]i in a time and concentration-dependent manner. After 20 minutes exposure to 5 mmol/L MgSO4, the OT-elicited changes in contractile response and [Ca2+]i were significantly decreased. MgSO4 did not change [Ca2+]i/force relationship of the responses to OT or KCl, or during spontaneous activity. At a pharmacologic concentration (5 mmol/L), MgSO4 inhibits contractile respons...Continue Reading

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Feb 26, 2004·American Journal of Obstetrics and Gynecology·Miguel E BermeoWilliam W Hurd

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Citations

May 25, 2013·International Journal of Obstetric Anesthesia·V P KovachevaL C Tsen
Mar 3, 2011·Cell Death & Disease·W H DribbenS Mennerick
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Mar 25, 2021·Reproductive Sciences·Konstantinos NirgianakisMichael D Mueller

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