Effect of magnesium supplementation on insulin resistance in humans: A systematic review

Nutrition
Jennifer Beatriz Silva MoraisKaroline de Macedo Gonçalves Frota

Abstract

Recent studies have demonstrated that minerals play a role in glucose metabolism disorders in humans. Magnesium, in particular, is an extensively studied mineral that has been shown to function in the management of hyperglycemia, hyperinsulinemia, and insulin resistance (IR) action. The aim of this study was to investigate the effect of magnesium supplementation on IR in humans via systematic review of the available clinical trials. This review was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations. A survey was conducted to select clinical trials related to the effects of this mineral in insulin sensitivity using the following databases: PubMed, SciVerse Scopus, ScienceDirect, and SciVerse Cochrane. After the selection process, 12 articles were identified as eligible, representing different clinical conditions and being free of restriction with regard to sex, age, ethnicity, and differential dosing/shape of magnesium. The results of eight clinical trials showed that supplementation with magnesium influences serum fasting glucose concentrations, and five trials determined an effect on fasting insulin levels. The results of seven studies demonstrated that mine...Continue Reading

Citations

Sep 2, 2018·Diabetes/metabolism Research and Reviews·Miji KimJesse Roth
May 1, 2018·Biological Trace Element Research·Solveig Meyer MikalsenJan Aaseth
Jun 1, 2018·International Journal of Endocrinology·Abdullah M Al AlawiHenrik Falhammar
Dec 6, 2018·Nutrients·Mohammed S Razzaque
Sep 7, 2018·Current Diabetes Reports·Willy Marcos ValenciaStuti Dang
Nov 7, 2019·Current Developments in Nutrition·Kristen P HamiltonAmina Haggag
Apr 18, 2018·European Journal of Epidemiology·Sasiwarang Goya WannametheePeter H Whincup
Jun 4, 2019·Cell Metabolism·Rie OuchiTakanori Takebe
Apr 12, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Huiping LiKaijun Niu
Jul 3, 2021·Nutrients·Kamila Pokorska-NiewiadaMałgorzata Szczuko
Jul 13, 2021·Behavioural Brain Research·Monserrat Macías-CarballoConsuelo Morgado-Valle

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