Effect of Magnesium Supplementation on Circulating Biomarkers of Cardiovascular Disease.

Nutrients
Alvaro AlonsoPamela L Lutsey

Abstract

(1) Background: Magnesium supplementation may be effective for the prevention of cardiometabolic diseases, but the mechanisms are unclear. Proteomic approaches can assist in identifying the underlying mechanisms. (2) Methods: We collected repeated blood samples from 52 individuals enrolled in a double-blind trial which randomized participants 1:1 to oral magnesium supplementation (400 mg magnesium/day in the form of magnesium oxide) or a matching placebo for 10 weeks. Plasma levels of 91 proteins were measured at baseline with follow-up samples using the Olink Cardiovascular Disease III proximity extension assay panel and were modeled as arbitrary units in a log2 scale. We evaluated the effect of oral magnesium supplementation for changes in protein levels and the baseline association between serum magnesium and protein levels. The Holm procedure was used to adjust for multiple comparisons. (3) Results: Participants were 73% women, 94% white, and had a mean age of 62. Changes in proteins did not significantly differ between the two intervention groups after correction for multiple comparisons. The most statistically significant effects were on myoglobin [difference -0.319 log2 units, 95% confidence interval (CI) (-0.550, -0.088...Continue Reading

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Citations

Apr 4, 2021·Nutrients·Nicola Veronese, Mario Barbagallo

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Methods Mentioned

BETA
proteomic assay
blood draws
protein assays
proteomic profiling

Clinical Trials Mentioned

NCT02837328

Software Mentioned

SAS
Olink

Related Concepts

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