Effect of magnesium supplements on serum C-reactive protein: a systematic review and meta-analysis

Archives of Medical Science : AMS
Mohsen MazidiMaciej Banach

Abstract

The aim of the study was to undertake a systematic review and meta-analysis of prospective studies to determine the effect of magnesium (Mg) supplementation on C-reactive protein (CRP). Design: Systematic review and meta-analysis of randomised controlled trials (RCTs). Data sources: PubMed-Medline, Web of Science, Cochrane Database, and Google Scholar databases were searched (up until December 2016). Eligibility criteria: Randomized controlled trials evaluating the impact of Mg supplementation on CRP. We used random effects models meta-analysis for quantitative data synthesis. For sensitivity analysis was used the leave-one-out method. Heterogeneity was quantitatively assessed using the I2 index. Main outcome: Level of CRP after Mg supplementation. From a total of 96 entries identified via searches, eight studies were included in the final selection. The meta-analysis indicated a significant reduction in serum CRP concentrations following Mg supplementation (weighted mean difference (WMD) -1.33 mg/l; 95% CI: -2.63 to -0.02, heterogeneity p < 0.123; I2 = 29.1%). The WMD for interleukin 6 was -0.16 pg/dl (95% CI: -3.52 to 3.26, heterogeneity p = 0.802; I2 = 2.3%), and 0.61 mg/dl (95% CI: -2.72 to 1.48, p = 0.182, heterogeneity p ...Continue Reading

Citations

Mar 17, 2020·Nutrition Research Reviews·Arrigo F G CiceroUNKNOWN International Lipid Expert Panel
Jul 11, 2020·Journal of the American College of Nutrition·Taylor C Wallace
Dec 14, 2018·International Journal of Molecular Sciences·Rosa CasasEmilio Sacanella
Nov 20, 2019·International Journal of Environmental Research and Public Health·Iwona Markiewicz-GórkaNatalia Pawlas
Mar 1, 2019·Nutrients·Nicoline H J Leenders, Marc G Vervloet
Jan 14, 2021·Nutrients·Ligia J DominguezMario Barbagallo
Jan 28, 2021·Nutrients·Gabriele PiuriRoberta Cazzola
Apr 2, 2020·Blood Reviews·Jennifer GileThomas Witzig
Nov 23, 2020·Seminars in Cell & Developmental Biology·Jeanette A MaierAndré Mazur

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