PMID: 6113874Jun 1, 1981Paper

Effect of manipulating central catecholamines on puberty and the surge of luteinizing hormone and gonadotropin releasing hormone induced by pregnant mare serum gonadotropin in female rats

Brain Research
D K SarkarG Fink

Abstract

We have investigated the effect of manipulating central catecholamines on the timing of puberty (as assessed by vaginal opening) in female rats and the surge of luteinizing hormone (LH) and gonadotropin releasing hormone (GnRH) induced by pregnant mare serum gonadotropin (PMSG) in immature female rats. Manipulation of the catecholamines was carried out with either 6-hydroxydopamine (6-OHDA) administered with or without either desipramine (DMI) or pargyline, or alpha-methyl-p-tyrosine (alpha-MPT). The neonatal administration of 6-OHDA delayed puberty, an effect which was potentiated by pretreatment with DMI and was associated with a reduction in the rate of body growth. Catecholamine fluorescence in animals aged 60--65 days that had been treated with DMI followed by 6-OHDA was diminished only in the caudatus--putamen; treatment with 6-OHDA alone resulted in diminished fluorescence in the hypothalamus and in the intermediate but not the external layer of the median eminence. The neonatal administration of alpha-MPT had no significant effect on either the growth rate or the timing of puberty. Regular oestrous cycle occurred after puberty in animals treated with either 6-OHDA or alpha-MPT. The PMSG-induced LH surge was significantl...Continue Reading

References

Mar 1, 1978·Journal of Reproduction and Fertility·P C MacKinnonR Laynes
Feb 1, 1972·British Journal of Pharmacology·D W ClarkE L Phelan
Jul 1, 1968·Proceedings of the Society for Experimental Biology and Medicine·G D NiswenderL E Reichert
Jun 1, 1980·Endocrinology·J A Ramaley, C K Phares

❮ Previous
Next ❯

Citations

Feb 1, 1995·Cellular and Molecular Neurobiology·D Becú-Villalobos, C Libertun
Jan 1, 1983·Psychoneuroendocrinology·D K Sarkar
Jul 14, 2010·Philosophy, Ethics, and Humanities in Medicine : PEHM·Terry E Hill
Oct 12, 2010·Endocrinology·Sheila J SemaanAlexander S Kauffman
Sep 2, 2009·Alcoholism, Clinical and Experimental Research·W Les DeesJill K Hiney
Mar 5, 2014·Alcoholism, Clinical and Experimental Research·Vinod K SrivastavaWilliam L Dees
Jan 30, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A LafuenteA I Esquifino
Dec 1, 1986·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·N A SvendgaardA Brun
Feb 1, 1989·Journal of in Vitro Fertilization and Embryo Transfer : IVF·M M Seibel, D M Smith
Feb 13, 2001·Endocrine Reviews·E Terasawa, D L Fernandez
Sep 16, 2021·Alcoholism, Clinical and Experimental Research·William L DeesVinod K Srivastava

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.