PMID: 6407844Apr 1, 1983Paper

Effect of mannitol and plasma on the cytotoxicity of cisplatin

European Journal of Cancer & Clinical Oncology
E E HoldenerB Hoogstraten

Abstract

A soft agar cell culture for human granulocyte precursor cells (CFU-c) was used to assess the cytotoxic effect of cisplatin before and after preincubating the drug with either mannitol and/or fresh human plasma. Consistent growth inhibition of CFU-c was found with survival of 87, 64 and 34% at cisplatin concentrations of 10(-7) M, 10(-6) M and 10(-5) M respectively. Dose-related survival was not changed by preincubating cisplatin with mannitol in molar ratios of 1:100 and 1:1000 for 4 and 24 hr. Preincubating 10(-5) M cisplatin with human plasma increased CFU-c survival corresponding to a loss of activity of 92 and 98% after 4- and 24-hr preincubations respectively. No significant difference in survival of CFU-c was noted whether bone marrow cells were exposed to cisplatin in human plasma or in the ultrafiltrate of human plasma. Mannitol did not change the decrease in cisplatin activity due to plasma protein binding. These data indicate that the cytotoxic effect of cisplatin can be reduced by exposure to human plasma but not to mannitol.

References

Aug 1, 1970·Journal of Cellular Physiology·B L Pike, W A Robinson

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Citations

Jan 1, 1989·Cancer Chemotherapy and Pharmacology·B SchechterR Arnon
Jun 19, 1992·Pharmaceutisch Weekblad. Scientific Edition·T J HodesJ H Beijnen
Feb 21, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B PengD R Newell
Aug 1, 1993·Journal of Neurology, Neurosurgery, and Psychiatry·J D Pickard, M Czosnyka
Nov 1, 1989·Medical Toxicology and Adverse Drug Experience·M Y Huang, J Schacht

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