PMID: 2124181Jan 1, 1990Paper

Effect of mannitol, n-2-mercaptopropionyl glycine and sodium nitroprusside on EEG recovery following cerebral ischemia and reperfusion in the rat

The Chinese Journal of Physiology
T F Huang, L L Huang

Abstract

The efficacy of free radical scavengers (mannitol and n-2-mercaptopropionyl glycine) and a vasodilator (sodium nitroprusside) on the EEG recovery following cerebral ischemia was studied in the anesthetized rat. Global ischemia of brain was produced by the four-vessel occlusion for 30 min followed by 3 h reperfusion. Blood pressure, heart rate and EEG were monitored. The test agents were infused intravenously 15 min before and immediately after cerebral ischemia. The results indicate that mannitol 20-50 mg/kg, n-2-mercaptopropionyl glycine 10-20 mg/kg and sodium nitroprusside 20-50 micrograms/kg singly or in combination improved EEG recovery during reperfusion.

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