Effect of margin status on cervical intraepithelial neoplasia recurrence following LLETZ in women over 50 years

BJOG : an International Journal of Obstetrics and Gynaecology
R ManchandaM Shafi

Abstract

To establish the effect of margin status on recurrence following large loop excision of the transformation zone (LLETZ) in women over 50 years. Prospectively collected data of women over 50 years, who underwent LLETZ for suspected cervical intraepithelial neoplasia between 1998 and 2003, were analysed. Women were followed up for up to over 6 years. District colposcopy service based at a gynae-oncology cancer centre. The main outcome measure included histologically detected recurrence. Any abnormal cytology on follow up was also documented. Prospectively collected data were analysed from the colposcopy database. Recurrence was analysed using Kaplan-Meir plots and Cox regression. Fisher's exact test was used to determine the association between margins and grade. The Kruskal-Wallis and Mann-Whitney U tests were used to compare age and duration of follow up between groups. A total of 118 women underwent LLETZ and 92 were included in the final analysis. Margins were designated as clear (n = 62), involved (n = 22) or uncertain (n = 8). Histological recurrence occurred in 12 while abnormal cytology was demonstrated in 17 women. One woman with involved margins developed cervical cancer. Individuals with clear margins were less likely ...Continue Reading

References

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Citations

Jun 5, 2013·Obstetrics and Gynecology Clinics of North America·Silvio TattiWalter Prendiville
Feb 4, 2009·BJOG : an International Journal of Obstetrics and Gynaecology·S Ghaem-Maghami, W P Soutter
Dec 18, 2008·BJOG : an International Journal of Obstetrics and Gynaecology·A Thomas, T Ram
Nov 19, 2010·BJOG : an International Journal of Obstetrics and Gynaecology·S Ghaem-MaghamiWp Soutter
Sep 8, 2010·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Intira SriprasertJatupol Srisomboon
Apr 7, 2012·São Paulo Medical Journal = Revista Paulista De Medicina·Caroline Alves de OliveiraFlávia de Miranda Corrêa

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