Effect of marine oils supplementation on coagulation and cellular activation in whole blood

Lipids
B OsterudO Rekdal

Abstract

A study was performed to explore the effects of supplemental intake of various marine oils known to be part of the Eskimo diet. Healthy men and women (134) were randomly selected to consume 15 mL/d of oil from blubber of seal, cod liver, seal/cod liver, blubber of Minke whale, or no oil for ten weeks. Total cholesterol was unchanged in the oil groups, whereas high density lipoprotein cholesterol increased 7% in the seal/cod liver oil (CLO) group (P < 0.05) and 11% in the whale oil group (P < 0.005). Triacylglycerol was significantly reduced in the CLO group only. The concentration of prothrombin fragment 1 + 2 was reduced 25% (P < 0.05) after whale oil supplementation. No change in fibrinogen or factor VIIc was detected. Tumor necrosis factor generation in lipopolysaccharide (LPS)-stimulated blood was 30% reduced after whale oil (P < 0.05), but was unaffected by intake of seal or CLO. The LPS-induced tissue factor activity in monocytes was reduced to a significant degree only in the seal/CLO group (34%) and whale oil group (35%) (P < 0.05). The most dramatic change in thromboxane B2 in LPS-stimulated blood was seen after whale oil intake with 44% reduction (P < 0.01). Supplementation of a regular diet with a combination of seal...Continue Reading

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Citations

Feb 3, 2007·Lipids·Edel O ElvevollBjarne Osterud
Jan 1, 1996·Meat Science·E O ElvevollI Martinez
Jan 1, 1997·Nutrition Research Reviews·H H VorsterJ C Jerling
Feb 5, 2008·Atherosclerosis·Edel O ElvevollBjarne Østerud
Jun 1, 1997·Medical Hypotheses·J Opstvedt
Jun 27, 2002·Nutrition and Health·Bjarne Osterud, Edel O Elvevoll
Jan 23, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·P MarckmannJ Jespersen
Jan 6, 2016·The Cochrane Database of Systematic Reviews·Colleen Oliver, Helen Watson
Apr 11, 2020·The Cochrane Database of Systematic Reviews·Helen Watson, Caroline Stackhouse
Nov 10, 2017·Mediators of Inflammation·Mari Johannessen WalquistKarl-Erik Eilertsen
Jul 18, 2020·Frontiers in Pharmacology·Pauke Carlijn SchotsTerje Steinar Larsen

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