Effect of maternal fluoxetine administration on uterine blood flow, fetal blood gas status, and growth

Pediatric Research
Janna Leigh MorrisonDan Rurak

Abstract

Clinical depression, diagnosed in 5-15% of women during pregnancy, increases the risk of negative pregnancy outcomes including an increased incidence of low birth weight newborns and preterm delivery. Fluoxetine, a selective serotonin reuptake inhibitor, is often prescribed to treat depression due to its efficacy, high margin of safety, and mild side effects. However, fluoxetine initially increases plasma serotonin concentration, and serotonin causes uterine vasoconstriction in sheep, which could result in fetal hypoxemia. To assess fetal fluoxetine effects, late-gestation pregnant sheep were surgically prepared for the measurement of blood gases, heart rate, blood pressure, and uterine artery blood flow (n = 29). Ewes received a 70-mg bolus i.v. infusion of fluoxetine over 2 min in 10 mL of sterile water followed by continuous infusion at a rate of 100 microg/min for 8 d (n = 14), or continuous infusion of sterile water (n = 15). Transient decreases in uterine artery blood flow, fetal PO(2), and oxygen saturation were observed within the first 15 min after fluoxetine exposure, which did not return to normal values by 24 h. Fetal pH decreased and PCO(2) increased over the first 4 h with a return to normal by 24 h. However, ther...Continue Reading

References

Jan 1, 1978·Biology of the Neonate·W BermanA M Rudolph
Oct 1, 1986·American Journal of Obstetrics and Gynecology·A J LlanosJ T Parer
Aug 11, 1995·Science·M M Weissman, M Olfson
May 5, 1993·JAMA : the Journal of the American Medical Association·A PastuszakC Woodland
Dec 1, 1995·Journal of Clinical Psychopharmacology·D J Goldstein
Oct 3, 1996·The New England Journal of Medicine·C D ChambersK L Jones
Jan 23, 1997·The New England Journal of Medicine·I NulmanG Koren
Nov 1, 1995·Journal of the Society for Gynecologic Investigation·H L HedrianaW M Gilbert
Jan 26, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·J C AlvarezO Spreux-Varoquaux
Feb 16, 2000·Pharmacology & Therapeutics·C Hiemke, S Härtter
Apr 26, 2000·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·S MisriX Kostaras
Nov 18, 2000·Biological Psychiatry·L S CohenS M Bouffard

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Citations

Jul 19, 2002·Prenatal Diagnosis
Jan 6, 2010·Reproduction, Fertility, and Development·Natalee W Bessette, Dan W Rurak
Mar 24, 2012·American Journal of Epidemiology·Kristin PalmstenSonia Hernández-Díaz
Aug 19, 2007·American Journal of Respiratory and Critical Care Medicine·Enrica FornaroJaques Belik
Apr 23, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Cassidy DelaneySteven H Abman
Sep 8, 2009·Clinics in Perinatology·Amy L SalisburyBarry M Lester
Oct 22, 2008·Seminars in Perinatology·Jaques Belik
Jun 27, 2012·Birth Defects Research. Part A, Clinical and Molecular Teratology·Gillian E Hanley, Tim F Oberlander
Sep 11, 2004·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Daniel M Campagne
Jun 15, 2010·American Journal of Obstetrics and Gynecology·Samuel BauerMichael Myers
Mar 18, 2015·CNS Spectrums·Lyndsay Ammon AvalosDe-Kun Li
Nov 22, 2016·The Journal of Physiology·Peter R StoneUNKNOWN Maternal Sleep In Pregnancy Research Group, The University of Auckland
Jun 28, 2005·Journal of the Society for Gynecologic Investigation·Janna L MorrisonK Wayne Riggs
Aug 31, 2004·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Ronald N HinesPaige L Williams
Nov 13, 2002·Pharmacoepidemiology and Drug Safety
Jun 20, 2018·Journal of Pediatric Orthopedics·Cynthia ChenEmily R Dodwell
Oct 17, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Janna L MorrisonRoss L Tellam
Nov 30, 2018·Fundamental & Clinical Pharmacology·Xavier HumbertJoachim Alexandre
Sep 13, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Cassidy DelaneySteven H Abman
Feb 7, 2020·Physiological Reports·Tamara J VarcoeJanna L Morrison
Jun 14, 2020·The Journal of Physiology·Eric M SchraubenChristopher K Macgowan
Sep 15, 2017·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·An Qi DuanJanna L Morrison
Nov 3, 2005·Reproduction, Fertility, and Development·Janna L MorrisonDan W Rurak
Jan 28, 2004·Drug Metabolism and Disposition : the Biological Fate of Chemicals·John KimDan W Rurak
Sep 1, 2008·Infant Mental Health Journal·John N I DieterB Denise Raynor
Mar 29, 2002·Pediatric Research·Gideon Koren
Nov 28, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Rajan PoudelJanna L Morrison
Feb 11, 2019·Pediatric Research·Tuan Anh NguyenDan Rurak
Jan 20, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·An Qi DuanMike Seed
Jan 26, 2021·Journal of Developmental Origins of Health and Disease·Michael D WieseJanna L Morrison
Dec 9, 2020·Clinical Neuropharmacology·Yaşar Tanir, Yahya Esad Özdemir
May 25, 2021·Journal of Clinical Psychopharmacology·Paige D WartkoSascha Dublin

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