Effect of maternal folic acid supplementation on prostatitis risk in the rat offspring

International Urology and Nephrology
Jing ZhuZu-Yue Sun

Abstract

Folic acid (FA) intake has increased to high levels in many countries for the prevention of neural tube defects. However, the impact of excess FA intake, particularly before and during pregnancy, requires further investigation. Our aim was to investigate the effect of maternal folic acid supplementation on prostatitis risk in the rat offspring. Female SD rats were administrated with different doses of FA by oral gavage from 2 weeks prior to mating to GD14: 0 mg/kg (distilled water), 0.2 mg/kg FA and 2.0 mg/kg FA respectively. The male rat offspring from each maternal FA group were castrated on PND56 and injected different doses of 17β-estradiol (E2) subcutaneously for 30 days to induce prostatitis: 0 mg/kg (corn oil) and 1.25 mg/kg E2 respectively. At necropsy, the prostates were collected for histopathological analysis. Fasting blood was collected for the determination of serum E2, T, DHT, and folic acid levels. The expression of TNF-α, COX-2, and ER-α was determined by immunohistochemistry. High-dose (2.0 mg/kg) maternal folic acid supplementation significantly increased the proportion of prostatitis in FA(2.0) + E2(1.25) group (87.5%) compared with FA(0) + E2(1.25) group (25%). The inflammation was focal and severe, and larg...Continue Reading

References

May 1, 1971·Lancet·A Richens
Jan 6, 1973·Lancet·T W Sheehy
Nov 13, 2004·The Journal of Nutritional Biochemistry·Y I Kim
May 20, 2005·Endocrine Reviews·Jean M Kaufman, Alex Vermeulen
Jun 7, 2007·JAMA : the Journal of the American Medical Association·Bernard F ColeUNKNOWN Polyp Prevention Study Group
Dec 7, 2007·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·R Douglas WilsonUNKNOWN MOTHERISK
Mar 11, 2008·The American Journal of Clinical Nutrition·A David SmithHelga Refsum
Mar 3, 2009·Annals of the New York Academy of Sciences·Stuart J Ellem, Gail P Risbridger
Mar 12, 2009·Journal of the National Cancer Institute·Jane C FigueiredoJohn A Baron
Aug 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Steven W Bailey, June E Ayling
Sep 15, 2011·BioFactors·Domenica TaruscioAlberto Mantovani
Oct 11, 2012·The British Journal of Nutrition·Graham C Burdge, Karen A Lillycrop
Nov 6, 2012·Birth Defects Research. Part A, Clinical and Molecular Teratology·Leonie G MikaelRima Rozen
Jan 28, 2014·PloS One·Shaidah Deghan ManshadiYoung-In Kim
Sep 25, 2014·International Urology and Nephrology·Yu-ling JiaZu-Yue Sun
Nov 12, 2014·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Faiqa FayyazUNKNOWN APrON Study Team
Apr 9, 2016·Journal of Basic and Clinical Pharmacy·Anroop B Nair, Shery Jacob
Jun 9, 2016·Nutrition Reviews·Abee L BoylesPaul M Coates
Jun 15, 2016·Results and Problems in Cell Differentiation·Sarah J PotterTony DeFalco

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

JAMA : the Journal of the American Medical Association
Jill Jin
Clinical and Investigative Medicine. Médecine Clinique Et Experimentale
V M Whitehead, D S Rosenblatt
American Journal of Medical Genetics
N J Wald, A K Hackshaw
© 2022 Meta ULC. All rights reserved