Effect of Maternal Vitamin B12 Supplementation on Cognitive Outcomes in South Indian Children: A Randomized Controlled Clinical Trial

Maternal and Child Health Journal
Susan ThomasK Srinivasan

Abstract

Objectives To examine the effects of oral maternal vitamin B12 supplementation during pregnancy and early lactation on cognitive development in children. Method We studied 218 children born to mothers enrolled in a placebo-controlled, randomized trial of vitamin B12 supplementation during pregnancy through 6 weeks post-partum. Cognitive functions were assessed at 30 months using the Bayley Scales of Infant Development- 3rd edition (BSID III). The association of maternal sociodemographic characteristics, maternal biochemical status during pregnancy, birth weight and home environment with each sub-domain of BSID-III was examined using linear regression analysis. Separate multiple linear regression analyses for each of the BSID-III sub-domains with maternal trimester specific nutritional biomarker status was conducted. Results Children of mothers who received oral vitamin B12 supplementation had significantly higher scores on expressive language compared to children of mothers who received placebo (β = 0.14, P = 0.03). Children of mothers with elevated serum total homocysteine (tHcy) in the second and third trimesters of pregnancy had significantly lower scores on expressive language (β = - 0.18, P = 0.03 and β = - 0.19, P = 0.02,...Continue Reading

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Citations

Jul 4, 2019·Paediatrics and International Child Health·Chandrika AzadDipika Bansal
Apr 1, 2021·The Journal of Pediatrics·Rebecca D Ganetzky
Apr 4, 2021·Scientific Reports·Dhanya ParameshwaranTara C Thiagarajan
Mar 5, 2021·Journal of Internal Medicine·A D Smith, H Refsum
Aug 24, 2021·Journal of Nutritional Science·Catherine SchwingerTor A Strand
Mar 5, 2021·Journal of Pediatric Hematology/oncology·Ebru Yilmaz KeskinAdnan Karaibrahimoğlu

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