PMID: 8605725Mar 1, 1996Paper

Effect of matrix metalloproteinase inhibitors on tumor growth and spontaneous metastasis

Clinical & Experimental Metastasis
J G ConwayG M McGeehan

Abstract

Four potent, synthetic inhibitors of matrix metalloproteinases (MMPs) were assessed as inhibitors of tumor growth and spontaneous metastasis to the lung. Mat Ly Lu rat prostate tumor, LOX human melanoma and M27 murine Lewis lung tumor were implanted subcutaneously (s.c.) in mice and allowed to grow for 3-12 days. The lungs of the tumor-bearing mice were then removed and implanted s.c. into untreated mice, and the outgrowth of secondary tumors from the implanted lungs measured. The incidence and rate of outgrowth of secondary tumors increased with the length of primary tumor growth, validating these measurements as indices of spontaneous metastasis to the lung. Compounds were tested by s.c. implantation of minipumps which delivered compound throughout the period of primary tumor growth and spontaneous metastasis to the lung at steady-state drug concentrations orders of magnitude greater than the concentrations needed to either inhibit collagenase, gelatinase or stromelysin in vitro. Inhibitor treatment slowed the growth of primary s.c. Mat Ly Lu and LOX tumors by 40-60% but had no significant effect on the growth of primary M27 tumors. Surprisingly, inhibitor treatment had no significant effect on the ability of the lung to gene...Continue Reading

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Citations

Aug 1, 1998·European Journal of Pharmacology·G FerryG C Tucker
Feb 27, 2001·Current Opinion in Nephrology and Hypertension·R E JosephG B Appel
Jul 23, 1999·Annals of the New York Academy of Sciences·G C TuckerG Atassi
Nov 14, 1998·Annals of Medicine·C M FerrierD J Ruiter
Mar 9, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·H R LijnenD Collen
Sep 25, 1999·British Journal of Cancer·E A GarbettN J Brown
Nov 8, 2003·World Journal of Gastroenterology : WJG·Xiao-Min SunJie-Ping Yu
Jan 28, 2006·World Journal of Gastroenterology : WJG·Vesna V DragutinovićMiroslav M Vrvić
Mar 15, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Primo N LaraDavid R Gandara

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