Effect of Maytenus ilicifolia Mart. on pregnant mice

Contraception
T Montanari, Estela Bevilacqua

Abstract

Maytenus ilicifolia Mart. is used in Brazilian herbal medicine particularly for stomach disorders, but it is also used, as in other parts of South America, for fertility control. To verify its potential as an abortifacient, the lyophilized hydroalcoholic extract of its leaves was administered orally at a dose of 1000 mg/kg/day to mice between the first and third day of pregnancy (DOP), between the forth and sixth DOP, or between the seventh and ninth DOP. The extract caused a pre-implantation embryonic loss, but it did not have an effect on implantation or organogenesis. Morphological alterations of the reproductive system, not an embryotoxic effect, were not found. Estrogenic activity of the extract, exhibited by an uterotrophic effect, suggests that it may be interfering with the uterine receptivity to the embryo.

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Citations

Mar 11, 2010·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Oveis KarimaAli Akbar Moosavi Movahedi
May 9, 2012·Journal of Natural Products·Vânia A F F M SantosMaysa Furlan
Sep 28, 2007·Natural Product Reports·Jin-Ming GaoYasuo Konishi
Mar 31, 2007·Natural Product Research·Rivaldo NieroFranco Delle Monache
Jan 27, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Rafael C DutraJoão B Calixto
Apr 8, 2014·Chinese Journal of Natural Medicines·Afsar ShaikSaisaran Sibyala
Dec 30, 2009·Journal of Ethnopharmacology·Nelson Fernando Quallio MarquesPaulo Roberto Dalsenter
Jan 25, 2005·Fitoterapia·M R Duarte, M C Debur
Jan 11, 2005·Contraception·Tanise Gonçalves de FreitasTatiana Montanari
Apr 22, 2006·Contraception·Talieh KazerooniAlireza Sattar
Feb 19, 2008·Brazilian Journal of Biology = Revista Brasleira De Biologia·A J MossiS Echeverrigaray
Oct 31, 2017·Cannabis and Cannabinoid Research·Natasha R RyzEthan B Russo
Jan 10, 2016·Experimental Biology and Medicine·Elane Cristina Silva Dos SantosRita de Cássia da Silveira E Sá
Dec 8, 2019·Journal of Ethnopharmacology·Beatriz Martins de Sá HyacienthJosé Carlos Tavares Carvalho

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