Effect of mechanical stimulation on bone marrow stromal cell-seeded tendon slice constructs: a potential engineered tendon patch for rotator cuff repair

Biomaterials
Ting-Wu QinChunfeng Zhao

Abstract

Cell-based tissue engineered tendons have potential to improve clinical outcomes following rotator cuff repair, especially in large or massive rotator cuff tears, which pose a great clinical challenge. The aim of this study was to develop a method of constructing a functional engineered tendon patch for rotator cuff repair with cyclic mechanical stimulation. Decellularized tendon slices (DTSs) were seeded with BMSCs and subjected to cyclic stretching for 1, 3, or 7 days. The mechanical properties, morphologic characteristics and tendon-related gene expression of the constructs were investigated. Viable BMSCs were observed on the DTS after 7 days. BMSCs penetrated into the DTSs and formed dense cell sheets after 7 days of mechanical stretching. Gene expression of type I collagen, decorin, and tenomodulin significantly increased in cyclically stretched BMSC-DTS constructs compared with the unstrained control group (P < 0.05). The ultimate tensile strength and stiffness of the cyclically stretched tendon constructs were similar to the unstrained control group (P > 0.05). In conclusion, mechanical stimulation of BMSC-DTS constructs upregulated expression of tendon-related proteins, promoted cell tenogenic differentiation, facilitat...Continue Reading

References

Jan 1, 1994·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·C Neidlinger-WilkeL Claes
May 12, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·C Neidlinger-WilkeL Claes
Feb 13, 2004·The Journal of Bone and Joint Surgery. American Volume·Leesa M GalatzKen Yamaguchi
Sep 17, 2004·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·Kenji KashiwagiMitsuo Ochi
Jul 8, 2005·The American Journal of Sports Medicine·Tadanao FunakoshiShin-ichiro Nishimura
May 9, 2006·Journal of Shoulder and Elbow Surgery·Julie BishopEvan L Flatow
Nov 24, 2006·Advances in Experimental Medicine and Biology·Rita I Abousleiman, Vassilios I Sikavitsas
Aug 7, 2007·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·David L ButlerHani Awad
Dec 24, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Hiromichi OmaePeter C Amadio
Jan 30, 2010·Tissue Engineering. Part a·Sepideh SaberJames Chang
Mar 2, 2010·Journal of Shoulder and Elbow Surgery·Kathleen A DerwinJoseph P Iannotti
Mar 3, 2010·The Journal of Bone and Joint Surgery. American Volume·Jay D KeenerKen Yamaguchi
May 29, 2010·Journal of Biomaterials Science. Polymer Edition·Jongman LeeSoo Hyun Kim
Oct 16, 2010·Journal of Applied Physiology·Yu-Long SunPeter C Amadio
Feb 18, 2011·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Chih-Hwa ChenHsia-Wei Liu
Feb 22, 2011·The American Journal of Sports Medicine·Lawrence V GulottaScott A Rodeo
Aug 19, 2011·Technology and Health Care : Official Journal of the European Society for Engineering and Medicine·M PetriM Jagodzinski
Sep 8, 2011·Tissue Engineering. Part a·John G BarberWan-Ju Li
Jan 17, 2012·Journal of Shoulder and Elbow Surgery·Eric T RicchettiKathleen A Derwin
Feb 11, 2012·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Ting-Wu QinChunfeng Zhao
Mar 2, 2012·Journal of Biomedical Materials Research. Part a·Liang-Ju NingTing-Wu Qin
Mar 13, 2012·Cell Transplantation·Weiliang ShenHong-Wei Ouyang
Nov 28, 2012·Matrix Biology : Journal of the International Society for Matrix Biology·Andrew A DunkmanLouis J Soslowsky
Dec 18, 2012·Biotechnology and Bioengineering·Tao WangMing H Zheng
Apr 5, 2013·The Journal of Bone and Joint Surgery. American Volume·E Scott PaxtonLeesa M Galatz
Aug 29, 2013·JAMA : the Journal of the American Medical Association·Job HermansSita M A Bierma-Zeinstra
Aug 2, 2014·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Chian-Her LeeHsain-Chung Shen

❮ Previous
Next ❯

Citations

Feb 18, 2016·Stem Cells International·Arianna B LovatiMatteo Moretti
Feb 4, 2016·Stem Cells International·Daniel W Youngstrom, Jennifer G Barrett
Nov 2, 2016·Connective Tissue Research·Daniel W YoungstromJennifer G Barrett
Nov 20, 2016·Journal of Cellular Physiology·Yu YuanJun Zou
Apr 5, 2017·Journal of Tissue Engineering and Regenerative Medicine·Akhilandeshwari RavichandranSwee-Hin Teoh
Oct 7, 2017·Journal of Biomedical Materials Research. Part a·Jie-Liang YangTing-Wu Qin
May 16, 2018·Journal of Tissue Engineering and Regenerative Medicine·Qian LiuChunfeng Zhao
Aug 4, 2018·The American Journal of Sports Medicine·Cheng-Hao ZhangTing-Wu Qin
Oct 4, 2018·The American Journal of Sports Medicine·Darryl D D'LimaSeong Hwan Moon
Sep 7, 2019·Current Stem Cell Research & Therapy·Ying Chen, Liling Tang
Apr 10, 2019·Annals of Biomedical Engineering·Giuseppe TalòArianna B Lovati
Oct 3, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Joseph LongDeok-Ho Kim
Jul 4, 2018·Materials·Megane Beldjilali-LabroCécile Legallais
Apr 3, 2020·Biomedical Materials·Devina JaiswalSangamesh G Kumbar
Feb 20, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Tengfei ZhaoKan Xu
Nov 30, 2016·Journal of Biological Engineering·William J Hadden, Yu Suk Choi
Dec 11, 2019·Tissue Barriers·Sophia K TheodossiouNathan R Schiele
Oct 9, 2020·Stem Cells International·Renwang ShengJialin Chen
Oct 22, 2019·Journal of Biomechanics·Sophia K TheodossiouNathan R Schiele
Feb 13, 2021·Advanced Healthcare Materials·Chiara RinoldiWojciech Swieszkowski
Feb 5, 2021·Journal of Biomechanical Engineering·Sophia K TheodossiouNathan R Schiele
Apr 4, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sandra Ruiz-AlonsoJose Luis Pedraz
May 26, 2021·Journal of Tissue Engineering and Regenerative Medicine·Yongsheng LiHairong Liu
Aug 8, 2021·International Journal of Molecular Sciences·Clemens GögeleGundula Schulze-Tanzil
Jun 10, 2019·ACS Biomaterials Science & Engineering·Chiara RinoldiAli Tamayol
Sep 11, 2021·Npj Regenerative Medicine·Woochan KimJangho Kim

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA
Juan PanTing-Wu Qin
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
Juan PanTing-Wu Qin
© 2021 Meta ULC. All rights reserved