Effect of medetomidine on respiration and minimum alveolar concentration in halothane- and isoflurane-anesthetized dogs

American Journal of Veterinary Research
Phillip Lerche, William W Muir

Abstract

To evaluate the effect of medetomidine on minimum alveolar concentration (MAC), respiratory rate, tidal volume, minute volume (V(M)), and maximum inspiratory occlusion pressure (IOCP(max)) in halothane- and isoflurane-anesthetized dogs. 6 healthy adult dogs (3 males and 3 females). The MAC of both inhalants was determined before and 5, 30, and 60 minutes after administration of medetomidine (5 microg/kg, IV). Dogs were subsequently anesthetized by administration of halothane or isoflurane and administered saline (0.9% NaCl) solution IV or medetomidine (5 microg/kg, IV). Respiratory variables and IOCP(max) were measured at specific MAC values 15 minutes before and 5, 30, and 60 minutes after IV administration of medetomidine while dogs breathed 0% and 10% fractional inspired carbon dioxide (FICO2). Slopes of the lines for VM/FICO2 and IOCP(max)/FICO2 were then calculated. Administration of medetomidine decreased MAC of both inhalants. Slope of V(M)/FICO2 increased in dogs anesthetized with halothane after administration of medetomidine, compared with corresponding values in dogs anesthetized with isoflurane. Administration of medetomidine with a simultaneous decrease in inhalant concentration significantly increased the slope fo...Continue Reading

References

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Jun 17, 2004·American Journal of Veterinary Research·Phillip Lerche, William W Muir

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Citations

Mar 4, 2009·Journal of Feline Medicine and Surgery·Eduardo R MonteiroLuísa Z Furlan
May 10, 2008·Veterinary Anaesthesia and Analgesia·Asadollah Kariman, R Eddie Clutton
Sep 25, 2010·Veterinary Ophthalmology·Amber L LabelleCarrie B Breaux
Sep 5, 2019·The Veterinary Clinics of North America. Small Animal Practice·Alexander Valverde, Alicia M Skelding

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