Effect of medium-chain triglycerides on the release behavior of Endostar encapsulated PLGA microspheres

International Journal of Pharmaceutics
Boyu MengXiaojin Yin

Abstract

The incomplete release of Endostar from PLGA microspheres was observed in our previous study. In the present study, we focused on the effect of medium-chain triglycerides (MCT) on the in vitro/in vivo release behavior of Endostar encapsulated PLGA microspheres, which were prepared by a water-in-oil-in-water (W/O/W) double-emulsion method with or without MCT. The in vitro accumulated release of Endostar from microspheres co-encapsulated with 30% MCT was found to be 79.04% after a 30-day incubation period in PBS (pH 7.4) at 37 degrees C. However, the accumulated release of Endostar from MCT-free microspheres was found to be only 32.22%. Pouches containing Endostar encapsulated PLGA microspheres were implanted subcutaneously in rats. The effect of MCT on the in vivo release showed a similar trend to the in vitro release. After 30 days, only 9.87% of the total encapsulated Endostar was retained in microspheres co-encapsulated with 30% MCT, while 42.25% of Endostar was retained in MCT-free microspheres. The co-encapsulation of MCT provided the microspheres with a porous surface, which significantly improved the in vitro/in vivo release of Endostar from PLGA microspheres. In addition, in vitro experiments showed that MCT co-encapsula...Continue Reading

References

Mar 1, 1985·Journal of Biomedical Materials Research·G E VisscherG J Argentieri
Mar 4, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·T UrataH Nakano
Jul 8, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·M van de WeertD J Crommelin
Dec 5, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·T MoritaH Yoshino
Jan 13, 2001·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·T MoritaH Yoshino
Oct 2, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·M SandorE Mathiowitz
Feb 21, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ge JiangPatrick P DeLuca
Aug 15, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Juan WangSteven P Schwendeman
Mar 3, 2004·Biochemistry·Bing LiYongzhang Luo
Mar 17, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Camille BouissouChristopher Van Der Walle
Jul 9, 2004·Biochemical and Biophysical Research Communications·Xiaoyu WuYongzhang Luo
Jul 12, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Chang-Ming DongXin-De Feng

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