Effect of medroxyprogesterone pretreatment on pentagastrin-induced panic symptoms in females with panic disorder

Psychiatry Research
J Le MellédoN Lara

Abstract

Clinical observation, as well as epidemiological and research data, suggest that female gonadal hormones influence the course of panic disorder (PD). Panicogenic agents such as pentagastrin are useful tools with which to study the pathophysiology of panic attacks. Nine women with PD were randomly assigned to receive, in a crossover design, a 3-day pretreatment with medroxyprogesterone acetate (MP) prior to an injection of pentagastrin, and a 3-day pretreatment with a placebo prior to another injection of pentagastrin. The panic response and the anxiety response to pentagastrin were decreased after MP pretreatment. These preliminary results support the use of laboratory models for investigations of the interactions between progestins and anxiety.

References

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Citations

Dec 20, 2005·Psychopharmacology·Anna-Carin N-WihlbäckTorbjörn Bäckström
Nov 10, 2004·Clinical Psychology Review·Kristin Vickers, Richard J McNally
Apr 28, 2005·Expert Review of Neurotherapeutics·Jean-Michel Le Mellédo, Glen Baker
Feb 14, 2006·Depression and Anxiety·Thomas J RaedlerKlaus Wiedemann
Apr 21, 2018·Hormones and Behavior·Tania A ReynoldsJon K Maner

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