PMID: 9165140Apr 1, 1997Paper

Effect of megestrol acetate and prepulsid on nutritional improvement in patients with head and neck cancers undergoing radiotherapy

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
H C ChenJ H Hsu

Abstract

Anorexia is a common problem in cancer patients who receive radiotherapy. In this current study, we attempt to determine the effect of megestrol acetate and prepulsid on appetite and nutritional improvement in patients with head and neck cancers undergoing radiotherapy. One hundred twenty-nine consecutive patients with head and neck cancers treated between July 1993 and June 1994 were prospectively randomized to receive either megestrol acetate, 40 mg qid (megace group), prepulsid, 5 mg tid (cisapride group), or a placebo treatment (control group) during radiotherapy. Before radiotherapy, body weight (kg), appetite score, performance status, biochemical parameters and hematological parameters were evaluated, and the above-noted clinical and biochemical parameters were assessed and recorded every other week. All patients received 6- 10 MV X-rays or Co-60 gamma-ray to head and neck region for a full course of radiotherapy, 61.2-75.6 Gy/7-9 weeks. Forty-eight patients were enrolled in the megace group, 41 patients in the cisapride group, and 40 patients in the control group. At the 2nd, 4th, 6th and 8th week, as the radiation dose escalated, the megace group had significantly less body weight loss than did the cisapride and contro...Continue Reading

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Citations

Jul 8, 2009·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Shashank GargEric Winquist
Mar 20, 2002·Cancer Practice·L DaratsosF Mahmood
Dec 18, 2013·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Fan LiYi Xiang
Aug 21, 2013·Critical Reviews in Oncology/hematology·Albert TucaPere Gascón
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Nov 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tugba YavuzsenRuth Lagman
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Apr 2, 2013·The Cochrane Database of Systematic Reviews·Vicente Ruiz GarciaSylvia Bort-Marti
Aug 2, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A JatoiP L Nguyen

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