PMID: 9181518Mar 1, 1997Paper

Effect of melatonin and corticosteroid on in vitro cellular immune function in humans

Journal of Pineal Research
N RogersD Dawson

Abstract

It is well accepted that the immune system shows circadian rhythmicity and that circadian disruption can significantly alter indices of immune function. Recently, a functional link between the endocrine and immune systems has been proposed to explain circadian rhythms in immune activity. Of particular interest is the finding that hormones such as melatonin and corticosteroid are able to exert modulating effects on lymphocyte proliferation. Previous research examining the effects of melatonin in vitro, however, has produced equivocal results. The aim of this study, therefore, was to examine the effects of melatonin and corticosteroid, both separately and together, on mitogen-stimulated human lymphocyte proliferation. Purified human lymphocytes were stimulated with concanavalin A (Con A, 4 micrograms/mL). Melatonin and/or corticosteroid were added to the culture medium during incubation. All cultures were done in quadruplicate. As expected, corticosteroid (25-1,000 ng/mL) significantly reduced proliferation by between 30 and 60% in a dose-related manner (P < 0.0001). Melatonin alone (10-1,000 fmol/mL) did not significantly affect lymphocyte proliferation. However, when lymphocytes were cultured in the presence of melatonin and co...Continue Reading

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Citations

Mar 14, 2000·Journal of Neuroimmunology·N L CurrierS C Miller
Jun 18, 2003·Annals of the Rheumatic Diseases·M CutoloA Sulli
Apr 29, 1998·Annals of Medicine·D Dawson, C J van den Heuvel
Sep 24, 1998·Journal of Pineal Research·T H ChampneyL A Beausang
Aug 22, 2003·Experimental Dermatology·Roland LangRoland Brandstaetter
Jan 8, 2004·Acta Physiologica Hungarica·C S BedizR Mogulkoc
Aug 27, 2016·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Mauricio F FarezFrancisco J Quintana
Jan 8, 2000·Journal of Pineal Research·D L DrazenR J Nelson
Sep 14, 2004·Journal of Leukocyte Biology·Markus HanssonKristoffer Hellstrand
May 29, 2003·Canadian Journal of Physiology and Pharmacology·Krystyna Skwarlo-SontaBozenna Olszanska
Mar 28, 2001·Annals of the New York Academy of Sciences·R J Nelson, D L Drazen
Aug 29, 2020·European Journal of Pharmacology·Puneet Kaur Randhawa, Manish Kumar Gupta

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