Effect of melatonin and gabapentin on anxiety and pain associated with retrobulbar eye block for cataract surgery: a randomized double-blind study

Indian Journal of Pharmacology
Marzieh-Beigom KhezriAli Atlasbaf

Abstract

To compare the effect of melatonin and gabapentin on anxiety, pain, sedation scores, and satisfaction of surgeon in patients of cataract surgery. One hundred thirty patients aged between 35 and 85 years scheduled for cataract surgery were randomly allocated to three study groups to receive melatonin (6 mg), gabapentin (600 mg) or placebo 90 min before arrival in the operating room. Pain, anxiety, and sedation scores during block and surgery as well as the surgeon's satisfaction with the surgery were assessed. Anxiety scores decreased significantly in melatonin and gabapentin groups compared to the placebo group after premedication and extended to early postoperative period. The level of anxiety showed no statistically significant difference between melatonin and gabapentin groups at any time of measurement. There were significant differences between the pain scores during retrobulbar placement in gabapentin versus placebo (95% CI 3 to 4; P = 0.001) and melatonin (95% CI 3 to 4; P = 0.040) groups. Also, there were significant differences between the sedation scores during retrobulbar placement in gabapentin and placebo groups (95% CI 2 to 2.5; P = 0.046). The difference in sedation scores during retrobulbar placement in melatoni...Continue Reading

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Citations

Sep 1, 2015·Brain Research Bulletin·Jana TchekalarovaRichard Teke Ngomba
Sep 12, 2020·Pain Practice : the Official Journal of World Institute of Pain·Zhaoqi WangJun Ma
Sep 15, 2018·Anesthesiology and Pain Medicine·Fatemeh JavaherforooshzadehMansour Soltanzadeh
Oct 11, 2019·Journal of Obstetrics and Gynaecology of India·Marzieh Beigom KhezriNavid Mohammadi
Aug 31, 2019·Journal of Ophthalmology·Michael MimouniYoreh Barak
Dec 16, 2020·The Cochrane Database of Systematic Reviews·Bennedikte K MadsenJacob Rosenberg

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Methods Mentioned

BETA
sedation
hysterectomy

Clinical Trials Mentioned

NCT01200641

Software Mentioned

SPSS

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