Effect of melatonin on PCB (Aroclor 1254) induced neuronal damage and changes in Cu/Zn superoxide dismutase and glutathione peroxidase-4 mRNA expression in cerebral cortex, cerebellum and hippocampus of adult rats

Neuroscience Research
Prabhu VenkataramanJagadeesan Arunakaran

Abstract

Polychlorinated biphenyls (PCBs) are one of the environmental toxicants and neurotoxic compounds which induce the production of free radicals leading to oxidative stress. Free radicals represent a class of biologically generated species that pose a potential threat to neuronal survival. Cu/Zn superoxide dismutase (SOD) and glutathione peroxidase-4 (GPx-4) are the key cellular antioxidant enzymes by which neurons and other cells detoxify free radicals and protect themselves from damage. Melatonin, an indoleamine plays an important role in neurodegenerative diseases as an antioxidant and neuroprotector. The aim was to carry out to investigate the effect of melatonin on PCB (Aroclor 1254) induced changes in histomorphology and Cu/Zn SOD, GPx-4 mRNA expression in selected brain regions of adult rats. Group I: rats intraperitoneally (i.p.) administered with corn oil (vehicle) for 30 days. Group II: rats injected (i.p.) with Aroclor 1254 (PCB) at 2mg/kgbw/day for 30 days. Groups III and IV: rats (i.p.) received melatonin (5 or 10mg/kgbw/day) simultaneously with PCB for 30 days. Groups V and VI: rats (i.p.) received melatonin (5 or 10mg/kgbw/day) alone for 30 days. After 30 days, rats were sacrificed and the brain regions were dissect...Continue Reading

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Citations

Jan 25, 2012·TheScientificWorldJournal·Kandaswamy SelvakumarJagadeesan Arunakaran
Aug 12, 2014·Metabolic Brain Disease·Wojciech ŁuczajElżbieta Skrzydlewska
Dec 1, 2011·Neurochemical Research·Kandaswamy SelvakumarJagadeesan Arunakaran
Sep 11, 2014·Food & Function·Miguel Navarro-AlarcónAhmad Agil
Aug 29, 2019·Journal of Histotechnology·Hesham N Mustafa
May 2, 2018·Current Medicinal Chemistry·Geir BjorklundSalvatore Chirumbolo
Sep 26, 2020·Arhiv za higijenu rada i toksikologiju·Naciye Dilara ZeybekBelma Koçer-Gümüşel

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