PMID: 696342Aug 1, 1978Paper

Effect of melperone, two of its metabolites and thiothixene on central monoamine metabolism and prolactin levels in rodents

Acta Pharmacologica Et Toxicologica
F A WieselP Skett

Abstract

The effects of melperone and thiothixene on the concentrations of monoamine metabolites in brain and prolactin in the serum of rats and mice were determined. Both drugs increased brain concentrations of dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in a dose-dependent manner. 5-Hydroxyindoleacetic acid (5-HIAA) was unaffected. The effect of thiothixene was longer lasting and about 5 times greater than that of melperone. Melperone, but not thiothixene, increased levels of 3-methoxy-4-hydroxyphenylethylene glycol (MOPEG). Several hours after administration of melperone, levels of HVA and MOPEG were diminished. Both drugs increased prolactin concentrations in rat serum. Thiothixene was about 10 times more potent than melperone. Of two urinary metabolites of melperone investigated, one caused the same qualitative effects on monoamine metabolism as melperone itself but with reduced potency. The other metabolite was ineffective.

References

May 1, 1966·The Journal of Pharmacy and Pharmacology·S B Ross, A L Renyi
Aug 1, 1973·European Journal of Pharmacology·H H KellerA Pletscher
Jan 1, 1963·Acta Pharmacologica Et Toxicologica·A CARLSSON, M LINDQVIST

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Citations

Jan 1, 1979·Archiv für Psychiatrie und Nervenkrankheiten·L BjerkenstedtG Sedvall
Jan 1, 1989·Acta Psychiatrica Scandinavica. Supplementum·E G Christensson
Jan 1, 1989·Acta Psychiatrica Scandinavica. Supplementum·F A WieselC Halldin
Jan 1, 1989·Acta Psychiatrica Scandinavica. Supplementum·H Y MeltzerG A Gudelsky

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