Effect of membrane tension on the physical properties of DOPC lipid bilayer membrane.

Biochimica Et Biophysica Acta
A Srinivas ReddyMirianas Chachisvilis

Abstract

Molecular dynamics simulations of a dioleoylphosphocholine (DOPC) lipid bilayer were performed to explore its mechanosensitivity. Variations in the bilayer properties, such as area per lipid, volume, thickness, hydration depth (HD), hydration thickness (HT), lateral diffusion coefficient, and changes in lipid structural order were computed in the membrane tension range 0 to 15dyn/cm. We determined that an increase in membrane tension results in a decrease in the bilayer thickness and HD of ~5% and ~5.7% respectively, whereas area per lipid, volume, and HT/HD increased by 6.8%, 2.4%, and 5% respectively. The changes in lipid conformation and orientation were characterized using orientational (S(2)) and deuterium (S(CD)) order parameters. Upon increase of membrane tension both order parameters indicated an increase in lipid disorder by 10-20%, mostly in the tail end region of the hydrophobic chains. The effect of membrane tension on lipid lateral diffusion in the DOPC bilayer was analyzed on three different time scales corresponding to inertial motion, anomalous diffusion and normal diffusion. The results showed that lateral diffusion of lipid molecules is anomalous in nature due to the non-exponential distribution of waiting tim...Continue Reading

References

Aug 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·P G Saffman, M Delbrück
Mar 6, 1981·Biochimica Et Biophysica Acta·A JohannssonJ C Metcalfe
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·R Peters, R J Cherry
Jul 25, 1997·Biochimica Et Biophysica Acta·R J Clarke
Apr 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·S GudiJ A Frangos
Jul 2, 1998·Biophysical Journal·L A BagatolliG D Fidelio
Jun 27, 2000·Biophysical Journal·K OlbrichE Evans
Jun 27, 2000·Biophysical Journal·W RawiczE Evans
Feb 24, 2001·Advances in Colloid and Interface Science·R J Clarke
Mar 17, 2001·Chemistry & Biology·M A HaidekkerE A Theodorakis
Mar 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Boris Martinac, Owen P Hamill
Mar 26, 2004·Biophysical Journal·Hari LeontiadouSiewert J Marrink
Jun 11, 2004·Biophysical Journal·Justin Gullingsrud, Klaus Schulten
Aug 6, 2004·Biochemical Pharmacology·David J Roberts, Magali Waelbroeck
Nov 3, 2004·Biochimica Et Biophysica Acta·Anthony G Lee
May 25, 2005·The Journal of Chemical Physics·Matej Praprotnik, Dusanka Janezic
Oct 14, 2005·Journal of Computational Chemistry·James C PhillipsKlaus Schulten
Dec 2, 2005·Nature·James U Bowie
Dec 2, 2005·Nature·Harvey T McMahon, Jennifer L Gallop
Jan 27, 2006·American Journal of Physiology. Cell Physiology·Ayako MakinoGeert W Schmid-Schönbein
Feb 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Y GambinW Urbach
Apr 11, 2006·The Journal of Membrane Biology·Norbert KucerkaJohn F Nagle
Jul 21, 2006·The Journal of Physical Chemistry. B·Philip D BloodGregory A Voth
Jul 22, 2006·Biochemical and Biophysical Research Communications·Yan-Liang ZhangMirianas Chachisvilis
Oct 3, 2006·Biophysical Journal·Ana Vitória BotelhoMichael F Brown
Oct 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Mirianas ChachisvilisJohn A Frangos
Mar 21, 2007·Methods : a Companion to Methods in Enzymology·Christian KandtD Peter Tieleman
Jun 16, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Charles R White, John A Frangos
Sep 1, 2007·The Journal of Physical Chemistry. B·Hector Martinez-SearaRamon Reigada
Apr 2, 2008·The Journal of Chemical Physics·Shirley W I SiuRainer A Böckmann

❮ Previous
Next ❯

Citations

Mar 6, 2013·Biomechanics and Modeling in Mechanobiology·Luca Deseri, Giuseppe Zurlo
Nov 26, 2015·Journal of Chemical Information and Modeling·Christophe BovignyMatteo Dal Peraro
Jun 20, 2014·Biochimica Et Biophysica Acta·Jacob J KinnunMichael F Brown
Nov 13, 2015·The Journal of Physical Chemistry. B·Wei DingMario Orsi
Nov 12, 2015·Bioresource Technology·J J Gallardo-RodríguezJ J Chalmers
Jan 1, 2014·Biochimica Et Biophysica Acta·Jun Yu XieMikko Karttunen
Nov 3, 2016·Journal of Chemical Theory and Computation·Silvio OsellaStefan Knippenberg
Mar 3, 2017·Journal of the American Chemical Society·Silvio Osella, Stefan Knippenberg
Mar 17, 2017·Annual Review of Physical Chemistry·Elnaz AlipourGilbert C Walker
Aug 28, 2014·Analytical Chemistry·Jinghui WangSibani Lisa Biswal
Jun 30, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Eijiro MaedaTakeo Matsumoto
Aug 15, 2019·Physical Chemistry Chemical Physics : PCCP·K J MallikarjunaiahMichael F Brown
Aug 20, 2019·Physical Chemistry Chemical Physics : PCCP·Erika AloiRosa Bartucci
Jul 3, 2018·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Tomonori NomotoMasanori Fujinami
Dec 23, 2016·Proceedings of the National Academy of Sciences of the United States of America·Matthias GartenGilman E S Toombes
Aug 23, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Anabel-Lise Le RouxPere Roca-Cusachs
Apr 25, 2020·The Journal of Cell Biology·Aymeric Chorlay, Abdou Rachid Thiam
Jul 2, 2018·The Journal of Chemical Physics·Moynul HasanMasahito Yamazaki
Feb 18, 2020·Frontiers in Pharmacology·Qingjia ChiHuaping Liang
Jun 8, 2019·Physical Review Letters·Valeria LosassoJason Crain
Nov 17, 2020·Frontiers in Cellular and Infection Microbiology·Ann-Britt Schäfer, Michaela Wenzel
Feb 23, 2021·The Journal of Physical Chemistry. B·Mathieu L SimeralJason H Hafner
Jun 2, 2018·Biochimica Et Biophysica Acta. Biomembranes·Xinxin WoodwardChristopher V Kelly
Oct 3, 2018·Biochimica Et Biophysica Acta. Biomembranes·Hyea HwangJames C Gumbart
Oct 17, 2020·Journal of Biomolecular Structure & Dynamics·Hugo Aceves-LunaNorma Flores-Holguín
Mar 26, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Shixin LiTongtao Yue
Oct 7, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Vincent L ThomsRaghuveer Parthasarathy
Dec 10, 2013·Journal of Chemical Theory and Computation·Takaharu MoriYuji Sugita
Jul 27, 2018·Nano Letters·Susann SpindlerVahid Sandoghdar
May 8, 2014·The Journal of Physical Chemistry Letters·Hualin Li, Alemayehu A Gorfe
Oct 31, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Dominik DrabikArtu Ras Ulčinas
Oct 23, 2021·ACS Applied Materials & Interfaces·Eider Berganza, Michael Hirtz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.