PMID: 11337177May 5, 2001Paper

Effect of menthone on the in vitro percutaneous absorption of tamoxifen and skin reversibility

International Journal of Pharmaceutics
K ZhaoJ Singh

Abstract

The effect of penetration enhancer (i.e., 1, 2, 3 and 5% menthone in combination with 50% ethanol (EtOH)) was investigated on the in vitro percutaneous absorption of tamoxifen, and post-recovery epidermal permeability after removal of the above enhancer. The flux of tamoxifen with menthone in combination with 50% EtOH was significantly greater (P<0.05) than the control (50% EtOH). The flux of tamoxifen increased with increasing concentrations of menthone. The post-recovery flux through enhancer exposed epidermis was significantly decreased (P<0.05) as compared to pre-recovery. However, post-recovery flux of tamoxifen through the enhancer-exposed epidermis did not completely recover to the baseline (i.e., post-recovery flux through phosphate buffered saline, pH 7.4 treated epidermis).

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Aug 1, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·S Gao, J Singh
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Citations

Feb 20, 2016·Journal of Nanobiotechnology·Yu-Ling LinKuang-Wen Liao
Feb 11, 2016·Analytical and Bioanalytical Chemistry·Judith V RayMarina Resmini
Aug 22, 2009·Journal of Pharmaceutical Sciences·Srinivas S GodavarthyKhaled A M Gasem
Jan 29, 2013·International Journal of Pharmaceutics·Amit BhatiaOm Prakash Katare
Jul 30, 2010·International Journal of Pharmaceutics·K M YerramsettyK A M Gasem
Aug 23, 2008·Pharmacology, Biochemistry, and Behavior·Toyoshi Umezu
Jun 17, 2009·Journal of Cosmetic Dermatology·Samara EberlinMary Luci de Souza Queiroz
Jul 5, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Y S R KrishnaiahV Satyanarayana
Mar 31, 2015·Frontiers in Chemistry·David SchmitzMelanie Schnell
Dec 7, 2006·Clinical Rehabilitation·Chengqi HeMei Han
May 20, 2021·Anais Brasileiros De Dermatologia·Mariana Campos Souza MenezesLuiz Ronaldo Alberti

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