Effect of metabolic syndrome components and their clustering on carotid atherosclerosis in a sample of the general Japanese population

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Chiaki HirataMikio Arita

Abstract

The objective of this study was to investigate the impact of metabolic syndrome (MS) on carotid atherosclerosis in a Japanese population. A total of 1727 subjects (805 males and 922 females) were included. Intima-media thickness (IMT) was measured using ultrasonography. To evaluate the independent determinants of IMT, a stepwise multiple regression analysis was employed that included age, current smoking habit, LDL-C, HbA1c and the MS components (SBP, DBP, TG, HDL-C, FBG, and WC) as independent variables. Multivariate regression analyses were performed to determine the independent associations of the MS components with IMT. In males, age (β=0.383, P<0.001), SBP (β=0.237, P<0.001), LDL-C (β=0.188, P<0.001), current smoking habit (β=0.124, P=0.007) and HbA1c (β=0.110, P=0.014) were significantly associated with IMT. In females, age (β=0.474, P<0.001), SBP (β=0.130, P=0.003) and FBG (β=0.110, P=0.038) were significantly associated with IMT. The present study demonstrated that an elevated number of MS components, with or without central obesity, is associated with higher IMT. Among the analyzed components, hypertension has the strongest association with higher IMT.

References

Sep 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·J T Salonen, R Salonen
Dec 1, 1993·Stroke; a Journal of Cerebral Circulation·C Bonithon-KoppP Y Scarabin
Jan 1, 1997·The British Journal of Radiology·P S Sidhu, S R Desai
Apr 19, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Lynne E WagenknechtSteven M Haffner
Nov 6, 2003·JAMA : the Journal of the American Medical Association·Olli T RaitakariJorma S A Viikari
May 14, 2005·Stroke; a Journal of Cerebral Circulation·Bernhard IglsederBernhard Paulweber
Jun 23, 2005·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Nobukazu IshizakaMinoru Yamakado
Jan 18, 2006·Internal Medicine·Ryuichi KawamotoAtsushi Kamitani
Jul 11, 2006·Cardiovascular Ultrasound·Rebecca L PollexRobert A Hegele
Feb 3, 2007·Stroke; a Journal of Cerebral Circulation·Heather M JohnsonJames H Stein
May 26, 2007·Stroke; a Journal of Cerebral Circulation·Toshiharu NinomiyaYutaka Kiyohara
Aug 21, 2007·Journal of Atherosclerosis and Thrombosis·Megumi TeramuraYoshiki Nishizawa
Oct 13, 2009·Diabetes Research and Clinical Practice·Yuka MatobaRyoichi Takayanagi
Jan 28, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Young-Hoon LeeJin-Su Choi
Mar 24, 2011·Journal of Atherosclerosis and Thrombosis·Hiroyuki NodaUNKNOWN Defining Vascular Disease (DVD) Research Group
Jul 9, 2011·Journal of Atherosclerosis and Thrombosis·Yuji MatsuzawaTadashi Nakamura
Jun 29, 2012·Cardiovascular Diabetology·Marit HerderEllisiv B Mathiesen
Nov 1, 2013·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Panagiota PietriChristodoulos Stefanadis
Mar 14, 2014·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Aleksander PrejbiszAndrzej Januszewicz

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Citations

Jul 22, 2016·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Erfan AyubiAli Sanjari Moghaddam
Mar 3, 2017·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Olga VrizEduardo Bossone
Mar 10, 2017·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Emel AydinFatih Dede
Jan 20, 2017·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Shingo HosooKozo Nakamura
Jan 20, 2017·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hiroshi ItohMasami Tanaka
Oct 6, 2017·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Massimo LeggioAndrea Mazza
Oct 17, 2017·Journal of Hypertension·Cesare CuspidiGiuseppe Mancia

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