Effect of metformin therapy on circulating amino acids in a randomized trial: the CAMERA study.

Diabetic Medicine : a Journal of the British Diabetic Association
David PreissN Sattar

Abstract

To investigate whether metformin therapy alters circulating aromatic and branched-chain amino acid concentrations, increased levels amino acid concentrations, increased levels of which have been found to predict Type 2 diabetes. In the Carotid Atherosclerosis: Metformin for Insulin Resistance (CAMERA) study (NCT00723307), 173 individuals without Type 2 diabetes, but with coronary disease, were randomized to metformin (n=86) or placebo (n=87) for 18 months. Plasma samples, taken every 6 months, were analysed using quantitative nuclear magnetic resonance spectroscopy. Ten metabolites consisting of eight amino acids [three branched-chain (isoleucine, leucine, valine), three aromatic (tyrosine, phenylalanine, histidine) and two other amino acids (alanine, glutamine)], lactate and pyruvate were quantified and analysed using repeated-measures models. On-treatment analyses were conducted to investigate whether amino acid changes were dependent on changes in weight, fat mass or insulin resistance estimated using homeostasis model assessment (HOMA-IR). Tyrosine decreased [-6.1 μmol/l (95% CI -8.5, -3.7); P<0.0001], while alanine [42 umol/l (95% CI 25, 59); P<0.0001] increased in the metformin-treated group compared with the placebo-trea...Continue Reading

References

Feb 8, 2002·The New England Journal of Medicine·William C KnowlerUNKNOWN Diabetes Prevention Program Research Group
Mar 23, 2011·Nature Medicine·Thomas J WangRobert E Gerszten
Jul 16, 2011·PloS One·Zhonghao YuRui Wang-Sattler
Oct 11, 2011·Amino Acids·María M AdevaCristóbal Donapetry
Dec 18, 2012·European Heart Journal·Martin MagnussonOlle Melander
Aug 21, 2013·Metabolism: Clinical and Experimental·Geoffrey A WalfordJose C Florez
Mar 14, 2014·The Lancet. Diabetes & Endocrinology·David PreissNaveed Sattar
Jul 6, 2014·PloS One·Antonella NapolitanoDerek J Nunez
Mar 4, 2015·Metabolism: Clinical and Experimental·Brian A IrvingK Sreekumaran Nair

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Citations

Apr 11, 2018·Diabetic Medicine : a Journal of the British Diabetic Association·N SafaiUNKNOWN CIMT Trial Group
Jul 12, 2018·Current Opinion in Cardiology·Deirdre K TobiasPatrick R Lawler
Mar 25, 2018·Circulation. Genomic and Precision Medicine·Deirdre K TobiasSamia Mora
Aug 17, 2018·The Journal of Clinical Endocrinology and Metabolism·Leen M 't HartMarleen M J van Greevenbroek
Oct 30, 2016·International Journal of Epidemiology·Naomi J RankinNaveed Sattar
Oct 1, 2020·Trends in Pharmacological Sciences·Ling He
Aug 3, 2021·Frontiers in Pharmacology·Abdelrahim AlqudahLana McClements

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