Abstract
To investigate whether metformin therapy alters circulating aromatic and branched-chain amino acid concentrations, increased levels amino acid concentrations, increased levels of which have been found to predict Type 2 diabetes. In the Carotid Atherosclerosis: Metformin for Insulin Resistance (CAMERA) study (NCT00723307), 173 individuals without Type 2 diabetes, but with coronary disease, were randomized to metformin (n=86) or placebo (n=87) for 18 months. Plasma samples, taken every 6 months, were analysed using quantitative nuclear magnetic resonance spectroscopy. Ten metabolites consisting of eight amino acids [three branched-chain (isoleucine, leucine, valine), three aromatic (tyrosine, phenylalanine, histidine) and two other amino acids (alanine, glutamine)], lactate and pyruvate were quantified and analysed using repeated-measures models. On-treatment analyses were conducted to investigate whether amino acid changes were dependent on changes in weight, fat mass or insulin resistance estimated using homeostasis model assessment (HOMA-IR). Tyrosine decreased [-6.1 μmol/l (95% CI -8.5, -3.7); P<0.0001], while alanine [42 umol/l (95% CI 25, 59); P<0.0001] increased in the metformin-treated group compared with the placebo-trea...Continue Reading
References
Feb 8, 2002·The New England Journal of Medicine·William C KnowlerUNKNOWN Diabetes Prevention Program Research Group
Mar 2, 2002·Diabetes·Michael KrebsMichael Roden
Mar 3, 2009·Journal of Pharmaceutical and Biomedical Analysis·Taoguang HuoFamei Li
Aug 18, 2009·The Analyst·Pasi SoininenMika Ala-Korpela
Feb 23, 2010·Circulation. Cardiovascular Genetics·Svati H ShahWilliam E Kraus
Mar 23, 2011·Nature Medicine·Thomas J WangRobert E Gerszten
Jul 16, 2011·PloS One·Zhonghao YuRui Wang-Sattler
Oct 11, 2011·Amino Acids·María M AdevaCristóbal Donapetry
May 4, 2012·Diabetes·Alena StancákováMarkku Laakso
Oct 9, 2012·Diabetes·Anna FloegelTobias Pischon
Nov 7, 2012·Diabetes Care·Peter WürtzMika Ala-Korpela
Dec 18, 2012·European Heart Journal·Martin MagnussonOlle Melander
Aug 21, 2013·Metabolism: Clinical and Experimental·Geoffrey A WalfordJose C Florez
Mar 14, 2014·The Lancet. Diabetes & Endocrinology·David PreissNaveed Sattar
Jul 6, 2014·PloS One·Antonella NapolitanoDerek J Nunez
Dec 10, 2014·PLoS Medicine·Peter WürtzMika Ala-Korpela
Jan 13, 2015·Circulation·Peter WürtzVeikko Salomaa
Feb 20, 2015·Diabetologia·Therese TillinNish Chaturvedi
Mar 4, 2015·Metabolism: Clinical and Experimental·Brian A IrvingK Sreekumaran Nair
Citations
Apr 11, 2018·Diabetic Medicine : a Journal of the British Diabetic Association·N SafaiUNKNOWN CIMT Trial Group
Jul 12, 2018·Current Opinion in Cardiology·Deirdre K TobiasPatrick R Lawler
Mar 25, 2018·Circulation. Genomic and Precision Medicine·Deirdre K TobiasSamia Mora
Jan 20, 2017·Circulation. Cardiovascular Genetics·Ruben N EppingaPim van der Harst
Aug 17, 2018·The Journal of Clinical Endocrinology and Metabolism·Leen M 't HartMarleen M J van Greevenbroek
Jul 1, 2017·Scientific Reports·Zhi Yang TamUNKNOWN ActiFE Study Group
Dec 13, 2019·Mediators of Inflammation·Xiaoyu LiaoHongting Zheng
Jul 25, 2020·Obesity·Kati MokkalaKirsi Laitinen
Oct 30, 2016·International Journal of Epidemiology·Naomi J RankinNaveed Sattar
May 8, 2018·Diabetologia·Paul WelshNaveed Sattar
Sep 13, 2020·Microorganisms·Ceri ProffittSaeed Shoaie
Oct 1, 2020·Trends in Pharmacological Sciences·Ling He
Jun 2, 2021·BMJ Open Diabetes Research & Care·Mikael S HuhtalaKristiina Tertti
Jun 5, 2021·Frontiers in Endocrinology·Stephanie T ChungSheela N Magge
Aug 3, 2021·Frontiers in Pharmacology·Abdelrahim AlqudahLana McClements
Aug 14, 2020·Journal of Agricultural and Food Chemistry·Kang ChenBaoru Yang