Effect of metformin/irinotecan-loaded poly-lactic-co-glycolic acid nanoparticles on glioblastoma: in vitro and in vivo studies

Nanomedicine
Ali TaghizadehghalehjoughiA M Abd El-Aty

Abstract

The present study was designed to evaluate the effects of irinotecan hydrochloride (IRI)- or metformin hydrochloride (MET)-loaded poly-lactic-co-glycolic acid (PLGA) nanoparticles (NPs) for the treatment of glioblastoma multiforme using in vitro neuron and U-87 MG glioblastoma cell cultures and in vivo animal model. The cytotoxic and neurotoxic effects of pure drugs, blank NPs and MET- and IRI-loaded PLGA NPs were investigated in vitro (using methylthiazolyldiphenyl-tetrazolium bromide assay) and in vivo (using Cavalieri's principle for estimation of cancer volume). 1 and 2 mM doses of MET and MET-loaded PLGA NPs, respectively, significantly reduced the volume of extracted cancer. Consequently, MET- and IRI-loaded PLGA NPs may be a promising approach for the treatment of glioblastoma multiforme.

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Citations

Feb 9, 2021·Toxicology Reports·Giovanni MontealegreAdriana Rojas-Villarraga
Jun 4, 2020·Toxicology Reports·Atefeh VarmazyariYaroslav Mezhuev
Mar 30, 2021·Environmental Research·Periklis VardakasDemetrios Kouretas
Jul 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Laya KhoshtabiatMaryam M Matin
Jul 5, 2021·European Journal of Pharmacology·Dadong GuoHongsheng Bi
Sep 3, 2021·Journal of Molecular Neuroscience : MN·Yingchu GuXiangdong Chen

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