PMID: 6183792Oct 1, 1982

Effect of methylmercury exposure on different neurotransmitter systems in rat brain

Toxicology Letters
Y Tsuzuki


The effect of methylmercury (4.0 mg/kg/day, for 50 days) exposure was studied on various neurotransmitter systems in hypothalamus, pons-medulla, brain-stem, and striatum of rats. Although methylmercury exposure resulted in marked increases in dopamine (DA) content of various brain regions and in the brain-stem or striatal norepinephrine (NE) level, the level of metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) was markedly decreased in the same regions. On the other hand, concentrations of 5-hydroxyindoleacetic acid (5-HIAA) in various brain regions were considerably decreased in methylmercury-exposed rats. Similarly, the 5-hydroxytryptamine (5-HT) level was markedly decreased in the hypothalamus, brain-stem, and striatum.


Mar 1, 1977·Pharmazie in unserer Zeit·H E Geissler, E Mutschler
Sep 1, 1975·Neuroscience Letters·R Von Burg, T Landry

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Brain Chemistry
Hydroxyindoleacetic Acid
Methylmercury Compounds
August Rats

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