PMID: 16617739Apr 19, 2006Paper

Effect of methylprednisolone on the attention in patients with multiple sclerosis

Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
Alina KułakowskaJan J Braszko

Abstract

The aim of the study was to examine effects of high doses of intravenous methylprednisolone (MP, 1 g daily, for 5 days) on the sustained attention and attention focusing in multiple sclerosis (MS) patients with clinical relapse. Thirty four relapsing-remitting patients were included. The mean age was 39.4 (20-56) years, mean disease duration and mean Expanded Disability Status Scale scores were 6.6 (0.8-18) years and 4.1 (2.0-6.0), respectively. MS patients underwent psychological testing three times: before and immediately after MP treatment, and 6 months later. The trials: "100-7" and "months of year backwards", The Brickenkamp d2 test, and The Visual Continuous Attention Test (DAUF) were used. Thirty two control subjects (mean age 37.2 years) with ischialgia, not receiving steroids, underwent the same testing procedure two times: at admission and on 6th day of hospitalization. Before and immediately after MP treatment MS patient obtained significantly worse scores than controls on the DAUF test (significantly decreased number of correct reactions (p<0.05), significantly increased number of incorrect reactions (p<0.05), and significantly increased mean value of reaction times (p<0.05)). There were no significant differences w...Continue Reading

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