PMID: 6972936Jun 1, 1981Paper

Effect of methylprednisolone on the production of neutrophil migration inhibition factor by T lymphocytes (NIF-T)

Immunopharmacology
L G WongR H Weisbart

Abstract

Glucocorticoids may suppress cell-mediated immunity by inhibiting lymphocyte mediator production or reducing the responsiveness of target cells to these mediators. Our laboratory recently described a newly recognized T-lymphocyte mediator, neutrophil migration inhibition factor from T-lymphocytes (NIF-T). In this report we assessed the effect of glucocorticoids on NIF-T activity. Methylprednisolone (MP) at concentrations as low as 10-7 M inhibited NIF-T activity from peripheral blood lymphocytes (PBL) in response to staphylococcal protein A (SPA) and concanavalin A (Con A). However, MP at concentrations as high as 10-4 M did not after the responsiveness of neutrophils to NIF-T. Therefore, the effect of MP on NIF-T activity was due to inhibition of mediator production. The effect of MP on NIF-T production was reversible in 24 hours. This finding is consistent with the clinical observation that alternate day therapy does not suppress cell-mediated immunity. Serum taken from a patient as early as one hour after oral administration of 100 mg of prednisone inhibited NIF-T production in vitro; serum obtained at 48 hr after prednisone had no measurable effect on NIF-T activity, In addition. MP inhibited NIF-T production by previously ...Continue Reading

References

Jan 1, 1979·Annual Review of Pharmacology and Toxicology·J E Parrillo, A S Fauci
Jan 1, 1977·Journal of Immunological Methods·R H Weisbart, M R Mickey
Mar 1, 1976·Annals of Internal Medicine·A S FauciJ E Balow
Apr 1, 1973·The Journal of Experimental Medicine·J E Balow, A S Rosenthal
Aug 24, 1972·The New England Journal of Medicine·H N Claman

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Citations

Jan 1, 1991·Comparative Immunology, Microbiology and Infectious Diseases·J M MolinaE Serrano

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