PMID: 4205Dec 1, 1975

Effect of metiamide on acid secretion from isolated kitten fundic mucosa

Canadian Journal of Physiology and Pharmacology
B L TeppermanF S Tepperman


Isolated kitten fundic mucosa demonstrates low rates of spontaneous acid secretion in vitro when bathed in Krebs-Henseleit solution, and responds consistently to histamine, pentagastrin, and acetylcholine placed in the bath. High rates of spontaneous secretion or secretion in response to histamine and pentagastrin were significantly inhibited by addition of metiamide (5 X 10(-3) M); but mucosa stimulated by constant addition of acetylcholine chloride (10(-4) M) was not inhibited by metiamide at the same concentration.


Apr 1, 1984·Agents and Actions·G CoruzziG Bertaccini
Nov 1, 1985·British Journal of Pharmacology·J W Black, N P Shankley
Apr 1, 1992·Nursing Diagnosis : ND : the Official Journal of the North American Nursing Diagnosis Association·L L Ouellet, K L Rush

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