PMID: 697342Sep 1, 1978Paper

Effect of microbial and tumor cell adaptation to rubomycin on their uptake of rubomycin and carminomycin

Antibiotiki
L N OstaninaV A Liashenko

Abstract

Anthracycline antibiotics rubomycin (daunomycin) and carminomycin rapidly accumulated in the bacterial and ascitic tumor cells and their intracellular concentrations significantly exceeded the concentrations in the medium. The strains of Staph. aureus and Fisher mouse ascitic lymphadenosis L-5178/P resistant to rubomycin preserved sensitivity to carminomycin. The resistance of the bacterial and tumor strains to rubomycin was accompanied by a significant decrease in the accumulation of rubomycin in the cells. At the same time carminomycin also effectively accumulated in the cells of Staph. aureus and Fisher ascitic lymphadenosis adapted to rubomycin, the same as in the cells of the parent strains.

Related Concepts

Related Feeds

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.