Effect of microencapsulated ampicillin on cell-mediated immune responses in mice

The Journal of Antimicrobial Chemotherapy
I S BarsoumJ A Setterstrom

Abstract

The effects of free ampicillin, microencapsulated ampicillin anhydrate (MEAA) and antibiotic-free microspheres on the cell-mediated immune response in Balb/c mice were measured by lymphoproliferation assay, delayed-type hypersensitivity (DTH) and cytokine production. Injection into mice for seven consecutive days with equivalent subcutaneous doses of ampicillin, MEAA or placebo microspheres did not produce any consistent change in lymphocyte proliferation nor did it affect DTH responses or interleukin-2 production. Although the production of interleukin-4 in mice treated with ampicillin or MEAA increased compared with the control mice, this increase was not statistically significant. These results indicate that ampicillin and MEAA have similar effects on cell-mediated immunity in mice.

Citations

Jun 30, 2011·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Carla Castiglia GonzagaHumberto Naoyuki Yoshimura
Feb 14, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Paulo Francisco CesarLeondardo Eloy Rodrigues Filho
May 10, 2017·Physical Chemistry Chemical Physics : PCCP·Xizheng WangMichael R Zachariah
Aug 28, 2007·Journal of Colloid and Interface Science·Dewei XuK Ravi-Chandar

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