Effect of microneedle design on pain in human volunteers.

The Clinical Journal of Pain
Harvinder S GillMark R Prausnitz

Abstract

To design microneedles that minimize pain, this study tested the hypothesis that microneedles cause significantly less pain than a 26-gauge hypodermic needle, and that decreasing microneedle length and the number of microneedles reduces pain in normal human volunteers. Single microneedles with lengths ranging from 480 to 1450 microm, widths from 160 to 465 microm, thicknesses from 30 to 100 microm, and tip angles from 20 to 90 degrees; and arrays containing 5 or 50 microneedles were inserted into the volar forearms of 10 healthy, human volunteers in a double-blinded, randomized study. Visual analog scale pain scores were recorded and compared with each other and to the pain from a 26-gauge hypodermic needle. All microneedles investigated were significantly less painful than the hypodermic needle with microneedle pain scores varying from 5% to 40% of the hypodermic needle. Microneedle length had the strongest effect on pain, where a 3-fold increase in length increased the pain score by 7-fold. The number of microneedles also affected the pain score, where a 10-fold increase in the number of microneedles increased pain just over 2-fold. Microneedle tip angle, thickness, and width did not significantly influence pain. Microneedles...Continue Reading

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Citations

Dec 17, 2009·Biomedical Microdevices·Seong-O ChoiMark G Allen
Jul 27, 2012·Biomedical Microdevices·Cheng Guo LiHyungil Jung
Nov 4, 2008·Pharmaceutical Research·Jason JiangMark R Prausnitz
Apr 14, 2010·Pharmaceutical Research·Yeu-Chun KimMark R Prausnitz
Nov 18, 2010·Pharmaceutical Research·Gary W Cleary
Dec 1, 2012·Pharmaceutical Research·Samantha N AndrewsMark R Prausnitz
Aug 2, 2013·Pharmaceutical Research·Bekir BedizO Burak Ozdoganlar
Jun 24, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Emilio Gonzalez-GonzalezRoger L Kaspar
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Jul 20, 2010·Nature Medicine·Sean P SullivanMark R Prausnitz
May 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Qiyun ZhuRichard W Compans
May 23, 2009·Diabetes Technology & Therapeutics·Jyoti GuptaMark R Prausnitz
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Jun 30, 2011·The Clinical Journal of Pain·Jyoti GuptaMark R Prausnitz
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Dec 3, 2014·Journal of Pharmaceutical Sciences·Matthew J MistilisMark R Prausnitz

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