Effect of microporation on passive and iontophoretic delivery of diclofenac sodium

Drug Development and Industrial Pharmacy
Hiren H PatelG Stagni

Abstract

Skin pretreatment with a microneedle roller (microporation (MP)) appears a simple and inexpensive technique to increase transdermal delivery of topically applied drug products. This study investigates the effect of MP on the passive and iontophoretic delivery of diclofenac (DCF) by quantifying dermis and plasma levels of DCF in a rabbit model. New Zealand albino female rabbits received either: (i) a topical application of 4 g of Voltaren® 1% gel with or without pretreatment with a microroller (0.5 mm needle length; density 23 microneedles per cm(2) area) or (ii) a DCF solution (40 mg/2.5 mL) via iontophoresis (IOMED transQ(E) medium size patch), with or without microroller pretreatment. A 300 µA/cm(2) cathodic current was applied for 20 min for a total of 80 mA. DCF concentrations were monitored in dermis with microdialysis sampling every 20 min for 5 h. Plasma samples were collected over the same period. In the passive delivery studies, microroller pretreatment increased Cmax by 1.5- and 2.0-fold in skin and plasma, respectively, and AUC by 1.5- and 2.4-fold in skin and plasma, respectively. In the iontophoresis delivery studies, microporation increased Cmax by 2.0-fold both in skin and in plasma, and AUC by 1.1- and 1.8-fold ...Continue Reading

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Citations

May 20, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Franciska ErdőYukio Kato
May 29, 2016·Journal of Pharmaceutical Sciences·Hiren PatelGrazia Stagni
Sep 15, 2016·Journal of Pharmaceutical Sciences·Sindhu S Ganti, Ajay K Banga
Apr 13, 2017·Journal of Pharmaceutical Sciences·Amit JoshiGrazia Stagni
Oct 27, 2020·Biomedical Microdevices·Leonna DsouzaShaila A Lewis

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