PMID: 11912281Mar 26, 2002Paper

Effect of mifepristone and levonorgestrel on expression of steroid receptors in the human Fallopian tube

Molecular Human Reproduction
A ChristowK Gemzell-Danielsson

Abstract

It is likely that mifepristone or levonorgestrel in the future will find extended use for contraceptive purposes. It is therefore essential to characterize the modes of action of these compounds. To assess the effect on the human Fallopian tube, 24 women with regular menstrual cycles and proven fertility, admitted to the hospital for voluntary sterilization by laparoscopic technique, were randomly allocated to a control or one of two treatment groups. Treatments were given with either a single dose of 200 mg mifepristone or 0.75 mg levonorgestrel in two doses 12 h apart, on day LH+2. Surgery was performed on day LH+4 to LH+6. Steroid receptor expression was analysed by immunohistochemistry, Western blot and RT-PCR. In the controls, there was a higher concentration of progesterone receptors in the stromal cells in the isthmic region than in those in the ampullar region. Treatment with mifepristone increased the progesterone receptor concentration in epithelial and stromal cells and increased the estrogen receptor concentration in epithelial cells. No effect on steroid receptor concentration was found following levonorgestrel. The contraceptive effect of post-ovulatory mifepristone has previously been considered to be dependent o...Continue Reading

Citations

Jan 12, 2010·Journal of Molecular Histology·Sanda Maria CretoiuL M Popescu
Feb 7, 2013·Best Practice & Research. Clinical Endocrinology & Metabolism·P G L LalitkumarKristina Gemzell-Danielsson
Apr 10, 2003·Contraception·Xiaoxi SunKristina Gemzell-Danielsson
Dec 31, 2003·Contraception·Kristina Gemzell-DanielssonLena Marions
Dec 31, 2003·Contraception·Horacio B Croxatto
Dec 12, 2003·Steroids·Kristina Gemzell DanielssonMarc Bygdeman
Oct 30, 2009·The Journal of Clinical Endocrinology and Metabolism·Andrew W HorneHilary O D Critchley
Nov 2, 2012·Contraception·Kristina Gemzell-DanielssonLalitkumar P G L
Feb 20, 2008·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Carlo BastianelliG Benagiano
Oct 12, 2010·Contraception·Kristina Gemzell-Danielsson
Oct 27, 2006·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Mari S GolubJames M Donald
Nov 20, 2014·Pharmacoepidemiology and Drug Safety·Alfonso CarvajalLuis García Sevillano
Apr 24, 2004·Contraception·Lena MarionsKristina Gemzell-Danielsson
Dec 18, 2010·Human Reproduction·R UdayashankarH D Moore
Feb 2, 2006·American Journal of Physiology. Endocrinology and Metabolism·Ruijin ShaoHåkan Billig
Jul 6, 2006·Molecular Human Reproduction·Kjell WånggrenK Gemzell-Danielsson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.