Effect of Milnacipran Treatment on Ventricular Lactate in Fibromyalgia: A Randomized, Double-Blind, Placebo-Controlled Trial

The Journal of Pain : Official Journal of the American Pain Society
Benjamin H NatelsonDikoma C Shungu

Abstract

Milnacipran, a serotonin/norepinephrine reuptake inhibitor, has been approved by the US Food and Drug Administration for the treatment of fibromyalgia (FM). This report presents the results of a randomized, double-blind, placebo-controlled trial of milnacipran conducted to test the hypotheses that a) similar to patients with chronic fatigue syndrome, patients with FM have increased ventricular lactate levels at baseline; b) 8 weeks of treatment with milnacipran will lower ventricular lactate levels compared with baseline levels and with ventricular lactate levels after placebo; and c) treatment with milnacipran will improve attention and executive function in the Attention Network Test compared with placebo. In addition, we examined the results for potential associations between ventricular lactate and pain. Baseline ventricular lactate measured by proton magnetic resonance spectroscopic imaging was found to be higher in patients with FM than in healthy controls (F1,37 = 22.11, P < .0001, partial η(2) = .37). Milnacipran reduced pain in patients with FM relative to placebo but had no effect on cognitive processing. At the end of the study, ventricular lactate levels in the milnacipran-treated group had decreased significantly c...Continue Reading

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Citations

Mar 1, 2018·The Cochrane Database of Systematic Reviews·Patrick WelschWinfried Häuser
Feb 14, 2019·Rheumatology International·Ilke Coskun Benlidayi
Jan 9, 2018·Fatigue : Biomedicine, Health & Behavior·Benjamin H NatelsonDikoma C Shungu
Feb 7, 2018·The American Journal of the Medical Sciences·Nian-Sheng TzengWu-Chien Chien
May 16, 2021·Expert Review of Clinical Pharmacology·Filippo MiglioriniGiorgia Colarossi
Jul 24, 2021·British Medical Bulletin·Filippo MiglioriniGiorgia Colarossi

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