Effect of minimal enteral feeding on recovery in a methotrexate-induced gastrointestinal mucositis rat model

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
Nicoline S S KuikenWim J E Tissing

Abstract

Patients suffering from gastrointestinal mucositis often receive parenteral nutrition as nutritional support. However, the absence of enteral nutrition might not be beneficial for the intestine. We aimed to determine the feasibility of minimal enteral feeding (MEF) administration in a methotrexate (MTX)-induced mucositis rat model and thereby determine the effect of MEF on recovery. Male Wistar rats were attached to swivel systems from day 1 to 5 after 45 mg/kg MTX IV injection. The MTX group continued ad libitum feeding, and the MTX + MEF group continued ad libitum feeding and received from day 1 to 5 continuously MEF. MEF consisted of 20 % of their normal caloric intake. We measured body weight, intake, and plasma citrulline. At day 10, the rats were terminated and villus and crypt length were measured. The administration of MEF caused no increased severity of mucositis phenotype, with comparable caloric intake, body weight, and plasma citrulline during mucositis. The recovery of plasma citrulline levels was not different between both groups. At day 7 and 8, the MTX + MEF group gained significantly more weight (p < 0.05 and p < 0.01, respectively), and at day 8 and 9 the total caloric intake was significantly increased (p < 0...Continue Reading

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Citations

Nov 20, 2016·Journal of Pediatric Gastroenterology and Nutrition·Nicoline S S KuikenWim J E Tissing
Mar 30, 2019·Current Opinion in Supportive and Palliative Care·Hannah R WardillAndrea M Stringer
Apr 28, 2017·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Nicoline S S KuikenWim J E Tissing
Oct 28, 2017·American Journal of Physiology. Gastrointestinal and Liver Physiology·Per T SangildMathias Rathe
Jun 16, 2021·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Hannah R WardillHermie J M Harmsen

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