Effect of minodronic acid hydrate on hip geometry in Japanese women with postmenopausal osteoporosis.

Journal of Bone and Mineral Metabolism
Masako ItoMasao Fukunaga

Abstract

Dual-energy X-ray absorptiometry-based hip structural analysis was performed to evaluate the effect of a bisphosphonate, minodronic acid hydrate, on the geometry of the proximal femur in Japanese patients with osteoporosis. The subjects were 103 postmenopausal patients (average age 63.9 +/- 6.4 years) with primary osteoporosis. Minodronic acid hydrate was administered orally at a dose of 1 mg/day for 12 months. Significant early responses at 3-6 months after the start of administration were observed in all three regions of the proximal femur (narrow neck, intertrochanter, and shaft) in terms of bone density, geometry, and bone strength indices. The outcomes of therapy included a reduction of the internal diameter of the cortical bone (-0.1, -0.6, and -0.2% in the neck, intertrochanter, and shaft, respectively, at 12 months; not significant) and a significant increase in cortical thickness (3.1, 3.7, and 2.0% in the respective regions at 12 months). Furthermore, minodronic acid hydrate induced a significant enlargement of the cross-sectional bone area, which is related to compressive strength; a significant increase in cross-sectional moment of inertia and section modulus (SM 4.9, 5.8, and 2.9% in the neck, intertrochanter, and ...Continue Reading

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Citations

Feb 27, 2013·Clinical Interventions in Aging·Shinji Tanishima, Yasuo Morio
Dec 1, 2010·Journal of Bone and Mineral Metabolism·Junichi TakadaToshihiko Yamashita
Feb 9, 2011·Journal of Bone and Mineral Metabolism·Masako Ito
Jul 21, 2011·Journal of Bone and Mineral Metabolism·Shaohui ZongGaofeng Zeng
Oct 28, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Atsushi ImaiHiroshi Takagi
Apr 1, 2011·Drug Development and Industrial Pharmacy·Ting-Li LuTao Chen
Mar 29, 2013·Journal of Bone and Mineral Metabolism·Shuko NojiriHideaki Sowa

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