PMID: 324257May 26, 1977

Effect of minoxidil on blood pressure and hemodynamics in severe hypertension

The American Journal of Cardiology
R K BryanJ M Purdy

Abstract

Eighteen patients with diastolic hypertension (100 to 120 mm Hg), in addition to propranolol, 160 mg daily, and hydrochlorothiazide, 100 mg daily, received progressively increased doses of either minoxidil or placebo in a double-blind crossover study. With minoxidil (average dose 19.7 mg) blood pressure decreased from 165/109 to 138/89 mm Hg without the appearance of orthostatic hypotension. Hypertrichosis and fluid retention did occur, with an average weight gain of 1.8 kg, concomitant with an increased plasma volume. Pulse rate and cardiac output increased; no significant changes were observed in plasma renin activity, renal plasma flow, glomerular filtration rate or excretion of catecholamines or aldosterone. Minoxidil appears to be a useful antihypertensive drug for treating patients who do not respond adequately to therapy with diuretic and beta adrenergic blocking agents.

References

Jul 26, 1973·The New England Journal of Medicine·W A Pettinger, H C Mitchell
Mar 5, 1970·The New England Journal of Medicine·E GilmoreC A Chidsey
Nov 1, 1974·Scandinavian Journal of Clinical and Laboratory Investigation·D Falch, N Norman
Mar 1, 1974·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·M L Nusynowitz, R Blumhardt
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Citations

Feb 1, 1989·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·L M RuilopeL Raij
Nov 27, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Steven K Engle, David E Watson
Sep 1, 1989·Journal of Clinical Pharmacology·G P Reams, J H Bauer
Mar 1, 1983·International Journal of Dermatology·R M Ingles, T Kahn
Sep 1, 1986·Journal of Clinical Pharmacology·B F JohnsonJ Johnson
Jun 2, 2016·The Journal of Clinical Hypertension·Heiko M MundtUrs Benck
Sep 18, 2016·Toxicologic Pathology·Kyuri KimCardiac Hypertrophy Working Group of the Predictive Safety Testing Consortium
Nov 16, 1981·Klinische Wochenschrift·A MeierW H Ziegler
Apr 1, 1986·Klinische Wochenschrift·P GremingerW Vetter
Sep 8, 2011·The Journal of Clinical Hypertension·Jay N CohnAlexander M Shepherd
Apr 1, 1979·Journal of Clinical Pharmacology·V M CampeseV DeQuattro
Mar 1, 1981·Arthritis and Rheumatism·J A Mitas
Jun 3, 2015·Journal of Cardiovascular Pharmacology and Therapeutics·Meghan N McCombTien M H Ng

Related Concepts

Aldosterone, (11 beta,17 alpha)-Isomer
Diastolic Blood Pressure
Cardiac Output
Clinical Trials
Polychemotherapy
Hemodynamics
Sectrazide
Hypertensive Disease
Kidney
U 10858

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