Effect of misoprostol on bone mineral density in women with postmenopausal osteoporosis

Prostaglandins & Other Lipid Mediators
Levent YasarFehmi Yazicioğlu

Abstract

To evaluate the effect of misoprostol on bone mineral density in postmenopausal women. The study was performed in a randomized controlled prospective manner in 90 women with menopause at Süleymaniye Maternity and Women's Diseases Teaching and Research Hospital between January and December 2003. Cases were divided into three groups each consisting of 30 women who were in menopause for at least 1 year and had t-scores less than -1 by dual energy X-ray densitometry (DEXA). Group I was treated with misoprostol and calcium, Group II received tibolone and calcium and Group III was given calcium only and considered as control group. In all patients, bone mineral density in L1-L4 vertebrae, femur neck and Ward triangle were measured by DEXA and t and z scores were calculated. All groups were similar demographically. Bone mineral density in L1-L4 vertebrae, femur neck and Ward triangle in the group treated with misoprostol, increased by 5, 8.1 and 3.6%, respectively. In the tibolone group, bone mineral density in L1-L4 vertebrae, femur neck and Ward triangle increased by 8.3, 5.3 and 7.8%, respectively. There was not a significant difference in t and z-scores and bone mineral density measurements between misoprostol and tibolon groups. ...Continue Reading

References

Sep 1, 1978·Annals of Internal Medicine·J F AloiaK Ellis
Mar 1, 1989·Radiology·H K GenantS T Harris
Nov 1, 1988·Journal of Oral Pathology·S C Marks, S Miller
Jun 26, 1986·The New England Journal of Medicine·B L Riggs, L J Melton
Mar 1, 1996·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·R D WelchR H Browne
Jan 8, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Y F MaX J Li
Jul 10, 1999·Bioorganic & Medicinal Chemistry·L GilR N Young
Jul 20, 1999·Prostaglandins & Other Lipid Mediators·A S SonmezC J Chuong
Oct 3, 1999·Journal of the American Academy of Nurse Practitioners·C KellerC Mobley
Jul 19, 2002·JAMA : the Journal of the American Medical Association·Jacques E RossouwUNKNOWN Writing Group for the Women's Health Initiative Investigators
Mar 11, 2003·Climacteric : the Journal of the International Menopause Society·J RymerI Fogelman
Aug 15, 2003·Clinics in Geriatric Medicine·Jeri W Nieves
Sep 1, 2004·Maturitas·Helenius J Kloosterboer
Dec 2, 2004·The Journal of Clinical Endocrinology and Metabolism·P Hanifi-MoghaddamL J Blok

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Citations

Feb 11, 2012·Medicina oral, patología oral y cirugía bucal·Jose López-LópezJuan-Jose Segura-Egea
Oct 3, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Nefise Ahmet-CamciogluMustafa Kucuk
May 17, 2021·Cell Death & Disease·Huo-Liang ZhengSheng-Dan Jiang

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