Effect of mitogen-activated protein kinases on chemokine synthesis induced by substance P in mouse pancreatic acinar cells.

Journal of Cellular and Molecular Medicine
Raina Devi RamnathMadhav Bhatia

Abstract

Substance P, acting via its neurokinin 1 receptor (NK1 R), plays an important role in mediating a variety of inflammatory processes. Its interaction with chemokines is known to play a crucial role in the pathogenesis of acute pancreatitis. In pancreatic acinar cells, substance P stimulates the release of NFkappaB-driven chemokines. However, the signal transduction pathways by which substance P-NK1 R interaction induces chemokine production are still unclear. To that end, we went on to examine the participation of mitogen-activated protein kinases (MAPKs) in substance P-induced synthesis of pro-inflammatory chemokines, monocyte chemoanractant protein-1 (MCP-I), macrophage inflammatory protein-lalpha (MIP-lalpha) and macrophage inflammatory protein-2 (MIP-2), in pancreatic acini. In this study, we observed a time-dependent activation of ERK1/2, c-Jun N-terminal kinase (JNK), NFkappaB and activator protein-1 (AP-1) when pancreatic acini were stimulated with substance P. Moreover, substance P-induced ERK 1/2, JNK, NFkappaB and AP-1 activation as well as chemokine synthesis were blocked by pre-treatment with either extracellular signal-regulated protein kinase kinase 1 (MEK1) inhibitor or JNK inhibitor. In addition, substance P-indu...Continue Reading

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Citations

Jul 24, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Xiaoyun FangMin Yu
Jun 29, 2010·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Raina Devi RamnathMadhav Bhatia
Oct 7, 2009·Antioxidants & Redox Signaling·Madhav Bhatia
Feb 13, 2009·The Journal of Pharmacology and Experimental Therapeutics·Raina Devi RamnathMadhav Bhatia
Oct 20, 2011·Endocrinology·Iordanes KaragiannidesCharalabos Pothoulakis
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Jan 1, 2012·Scientifica·Madhav Bhatia
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Apr 2, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Bernardo Nuche-BerenguerR T Jensen
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Dec 28, 2007·American Journal of Physiology. Cell Physiology·Raina Devi RamnathMadhav Bhatia
Jul 25, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Joelle MesmarElias Baydoun

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Methods Mentioned

BETA
protein assay
ELISA
environmental stresses

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