Effect of mobile telephone reminders on treatment outcome in HIV: evidence from a randomised controlled trial in India

BMJ : British Medical Journal
Anita ShetVinod Diwan

Abstract

To assess whether customised mobile phone reminders would improve adherence to therapy and thus decrease virological failure among HIV infected patients starting antiretroviral treatment (ART). Randomised controlled trial among HIV infected patients initiating antiretroviral treatment. Three diverse healthcare delivery settings in south India: two ambulatory clinics within the Indian national programme and one private HIV healthcare clinic. 631 HIV infected, ART naïve, adult patients eligible to initiate first line ART were randomly assigned to mobile phone intervention (n=315) or standard care (n=316) and followed for 96 weeks.. The intervention consisted of customised, interactive, automated voice reminders, and a pictorial message that were sent weekly to the patients' mobile phones for the duration of the study. The primary outcome was time to virological failure (viral load >400 copies/mL on two consecutive measurements). Secondary outcomes included ART adherence measured by pill count, death rate, and attrition rate. Suboptimal adherence was defined as mean adherence <95%. Using an intention-to-treat approach we found no observed difference in time to virological failure between the allocation groups: failures in the inte...Continue Reading

Citations

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