Effect of moderate alcohol intake on lipid peroxidation in plasma, erythrocyte and leukocyte and on some antioxidant enzymes

Clinica Chimica Acta; International Journal of Clinical Chemistry
I AkkuşA Gürel

Abstract

Plasma, erythrocyte and leukocyte lipid peroxidation, erythrocyte superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and plasma gamma-glutamyl transferase (GGT) levels were investigated in 36 healthy non-drinkers aged between 18-55 years (mean 38.7) and 72 alcohol drinkers aged between 20-48 years (mean 35.3) in order to determine the oxidative effect of alcohol. Erythrocyte lipid peroxidation of the drinkers (measured in terms of MDA) was found to be significantly (P < 0.05) reduced compared to that of controls. However, when Tukey-HSD and F test with ANOVA were performed, that significance disappears in those who consume less than 140 g of alcohol per day and persists in those who consume more than 140 g of alcohol per day (P < 0.05). Plasma GGT level was significantly increased compared to that of controls (P < 0.001). Also, there was a significant (P = 0.01) correlation between serum GGT level and the amount of alcohol. There were no significant differences between all the other parameters of both groups. Reduced lipid peroxidation of erythrocytes without any accompanying increase in the activities of antioxidant enzymes shows that another mechanism might be responsible for this finding. This mechanism was thought ...Continue Reading

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Citations

Apr 12, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Pintu D Masalkar, Subodhini A Abhang
Sep 11, 2003·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Bozena Bukowska
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Mar 31, 2009·Arhiv za higijenu rada i toksikologiju·Alica PizentSpomenka Telisman
Mar 16, 2011·Veterinary Medicine International·Mahmoud Rushdi Abd Ellah
Aug 19, 2007·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Betul Karademir CatalgolBuket Alpertunga
Apr 1, 2006·Fundamental & Clinical Pharmacology·Vairappan Balasubramaniyan, Namasivayam Nalini
Feb 24, 2001·European Journal of Gastroenterology & Hepatology·K HagymásiJ Fehér
Oct 17, 2007·Molecular and Cellular Biochemistry·Aleksandra Rasić-MarkovićHelena Loncar-Stevanović
Oct 20, 2000·The Journal of Laboratory and Clinical Medicine·U Mutlu-TürkoğluM Uysal
Jun 8, 2006·Journal of Agricultural and Food Chemistry·Subhashinee S K Wijeratne, Susan L Cuppett

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